Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene
Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene
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DOI：
10.1038/tpj.2011.66
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发表时间：
2013-06-01
影响因子：
2.8
通讯作者：
Mueller, D. J.
中科院分区：
文献类型：
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作者：
Chowdhury, N. I.;Tiwari, A. K.;Mueller, D. J.
抗精神病药物诱导的体重增加(AIWG)可能导致精神分裂症(SCZ)患者的代谢综合征。黑素皮质素-4受体(MC4R)基因下游变异与不同人群的肥胖有关。因此，我们研究了MC4R区域的单核苷酸多态(SNPs)与SCZ患者AIWG的关联。对224例接受SCZ治疗的患者进行了4个SNP(rs2229616、rs17782313、rs11872992和rs8087522)的基因分型，并进行了长达14周的AIWG评估。我们使用三个SNP(r(2))的协方差分析比较了不同基因型组之间的体重变化(%)
Antipsychotic-induced weight gain (AIWG) may result in the metabolic syndrome in schizophrenia (SCZ) patients. Downstream variants of the melanocortin-4 receptor (MC4R) gene have been associated with obesity in various populations. Thus, we examined single-nucleotide polymorphisms (SNPs) in the MC4R region for association with AIWG in SCZ patients. Four SNPs (rs2229616, rs17782313, rs11872992 and rs8087522) were genotyped in 224 patients who underwent treatment for SCZ and were evaluated for AIWG for up to 14 weeks. We compared weight change (%) across genotypic groups using analysis of covariance for three SNPs (r(2)