The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population
The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population
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DOI：
10.1164/ajrccm.163.5.2007135
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发表时间：
2001-04-01
影响因子：
24.7
通讯作者：
Trevisan, M
中科院分区：
文献类型：
--
作者：
Schünemann, HJ;Grant, BJB;Trevisan, M
肺功能降低是一般人群死亡率的重要预测因素，抗氧化维生素被认为对肺功能有积极影响。维生素C、维生素E、视黄醇和类胡萝卜素是强有力的抗氧化剂，但关于这些抗氧化剂的血清水平与肺功能的联合关系的信息有限。我们在一项横断面研究中分析了FEV 1和FVC与血清维生素C和E、视黄醇和类胡萝卜素（β-隐黄质、叶黄素/玉米黄质、β-胡萝卜素和番茄红素）的关系。该分析是在美国纽约西部随机选择的1，616名居民的样本中进行的，这些居民年龄在35至79岁之间，没有呼吸道疾病。肺功能根据身高、年龄、性别和种族进行校正，并表示为预测正常FEV 1（FEV1%）和FVC（FVC%）的百分比。血清抗氧化剂水平最低四分位数的受试者FEV1%和FVC%始终低于四分位数较高的受试者。多元线性回归分析显示，维生素C、维生素E、β-隐黄素、叶黄素/玉米黄质、β-胡萝卜素和视黄醇与FEV1%显著相关，这些变量在调整其他协变量（吸烟状况、吸烟包年数、体重、嗜酸性粒细胞计数和教育）后单独研究。当在多变量回归模型中同时分析所有这些抗氧化维生素时，最强的关联与维生素E和β-隐黄素有关。在控制维生素E和β-隐黄素后，只有视黄醇对FEV1%显示出独立的影响。至于FEV1%，当在多变量回归模型中考虑所有变量时，维生素E和β-隐黄素与FVC%的相关性最强。与血清维生素E或β-隐黄质的一个标准差的降低相关的FEV 1的差异相当于大约1至2年老化的负面影响。我们的研究结果支持这样的假设，即抗氧化维生素可能在呼吸系统健康中起作用，维生素E和β-隐黄素似乎比其他抗氧化维生素与肺功能的相关性更强。
Reduced pulmonary function is an important predictor of mortality in the general population, and antioxidant vitamins are thought to positively influence pulmonary function. Vitamin C, vitamin E, retinol, and carotenoids are powerful antioxidants but information about the joint relation of serum levels of these antioxidants to pulmonary function is limited. We analyzed the association of FEV1 and FVC with serum vitamins C and E, retinol, and carotenoids (beta -cryptoxanthin, lutein/zeaxanthin, beta -carotene, and lycopene) in a cross-sectional study. The analysis was carried out in a sample of 1,616 randomly selected residents of Western New York, USA, age 35 to 79 yr and free of respiratory disease. Lung function was adjusted for height, age, sex, and race and expressed as percentage of predicted normal FEV1 (FEV1%) and FVC (FVC%). Participants in the lowest quartile of each of the serum antioxidants had consistently lower FEV1% and FVC% than those in higher quartiles. Multiple linear regression analysis revealed significant associations of vitamin C, vitamin E, beta -cryptoxanthin, lutein/zeaxanthin, beta -carotene, and retinol with FEV1% when these variables were investigated individually after adjustment for other covariates (smoking status, pack-years of smoking, weight, eosinophil count, and education). When all of these antioxidant vitamins were analyzed simultaneously in a multivariate regression model, the strongest association was seen with vitamin E and beta-cryptoxanthin. Only retinol showed an independent effect on FEV1% after controlling for vitamin E and beta -cryptoxanthin. As for FEV1%, vitamin E and beta -cryptoxanthin were most strongly related to FVC% when all variables were considered in the multivariate regression model. The differences in FEV1 associated with a reduction of one standard deviation of serum vitamin E or beta -cryptoxanthin were equivalent to the negative influence of approximately 1 to 2 yr of aging. Our findings support the hypothesis that antioxidant vitamins may play a role in respiratory health and that vitamin E and beta -cryptoxanthin appear to be stronger correlates of lung function than other antioxidant vitamins.