Glucose Metabolic Changes in the Brain and Muscles of Patients with Nonspecific Neck Pain Treated by Spinal Manipulation Therapy: A [(18)F]FDG PET Study.
Glucose Metabolic Changes in the Brain and Muscles of Patients with Nonspecific Neck Pain Treated by Spinal Manipulation Therapy: A [(18)F]FDG PET Study.
复制标题
通过脊柱操纵疗法治疗的非特异性颈部疼痛患者的大脑的葡萄糖代谢变化：A [（18）F] FDG PET研究。
DOI：
10.1155/2017/4345703
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Tashiro M
中科院分区：
文献类型：
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作者：
Inami A;Ogura T;Watanuki S;Masud MM;Shibuya K;Miyake M;Matsuda R;Hiraoka K;Itoh M;Fuhr AW;Yanai K;Tashiro M
目标。本研究的目的是利用[18F]氟脱氧葡萄糖（[18F]FDG PET）正电子发射断层扫描研究尚不清楚的脑和肌肉葡萄糖代谢的变化。方法。本研究招募了21名男性志愿者。[18F]每位受试者进行两次FDG PET扫描：一次是在脊柱推拿疗法（SMT）干预后（治疗组），一次是在休息后（对照组）。我们使用调节装置进行SMT干预。测量并比较了两种情况下大脑和骨骼肌的葡萄糖代谢。此外，我们测量了唾液淀粉酶水平作为自主神经系统（ANS）活动的指标，以及每个受试者的肌肉张力和主观疼痛强度。结果。SMT后大脑活动的变化包括前扣带背皮层、小脑蚓部和体感觉关联皮层的激活以及前额叶皮层和颞叶部位的失活。SMT后骨骼肌葡萄糖摄取呈代谢降低的趋势，但差异不显著。其他测量结果显示，SMT后颈肌张力放松，唾液淀粉酶水平降低（交感神经活动抑制），疼痛缓解。结论。SMT后的大脑加工可能通过交感神经活动的减少而导致生理放松。
Objective. The aim of this study was to investigate changes in brain and muscle glucose metabolism that are not yet known, using positron emission tomography with [18F]fluorodeoxyglucose ([18F]FDG PET). Methods. Twenty-one male volunteers were recruited for the present study. [18F]FDG PET scanning was performed twice on each subject: once after the spinal manipulation therapy (SMT) intervention (treatment condition) and once after resting (control condition). We performed the SMT intervention using an adjustment device. Glucose metabolism of the brain and skeletal muscles was measured and compared between the two conditions. In addition, we measured salivary amylase level as an index of autonomic nervous system (ANS) activity, as well as muscle tension and subjective pain intensity in each subject. Results. Changes in brain activity after SMT included activation of the dorsal anterior cingulate cortex, cerebellar vermis, and somatosensory association cortex and deactivation of the prefrontal cortex and temporal sites. Glucose uptake in skeletal muscles showed a trend toward decreased metabolism after SMT, although the difference was not significant. Other measurements indicated relaxation of cervical muscle tension, decrease in salivary amylase level (suppression of sympathetic nerve activity), and pain relief after SMT. Conclusion. Brain processing after SMT may lead to physiological relaxation via a decrease in sympathetic nerve activity.