Architecture and function in the muscle sarcomere
Architecture and function in the muscle sarcomere
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DOI：
10.1016/s0959-440x(97)80033-4
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发表时间：
1997-04-01
影响因子：
6.8
通讯作者：
Squire, JM
中科院分区：
文献类型：
--
作者：
Squire, JM
脊椎动物中的横纹肌肉肌节由肌动蛋白和肌球蛋白细丝有序排列组成，由精心制作的蛋白质支架组织。最近在一些实验室进行的创新工作极大地提高了我们对这些结构、它们的组织及其相互作用的了解。肌球蛋白细丝、肌动蛋白细丝、Z带、M带、肌动蛋白和星云蛋白的结构细节已有报道。时间分辨X射线衍射和电子显微镜正在揭示与力的产生和调节有关的分子运动。
Striated muscle sarcomeres in vertebrates comprise ordered arrays of actin and myosin filaments, organized by an elaborate protein scaffold. Recent innovative work in a number of laboratories has greatly improved our knowledge of these structures, their organization and their interactions. Structural details have been reported on myosin filaments, actin filaments, Z-bands, M-bands, titin, and nebulin. Time-resolved X-ray diffraction and electron microscopy are revealing the molecular movements involved in force production and regulation.