OLFACTORY FUNCTION IN ATYPICAL PARKINSONIAN SYNDROMES
OLFACTORY FUNCTION IN ATYPICAL PARKINSONIAN SYNDROMES
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DOI：
10.1111/j.1600-0404.1995.tb06998.x
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发表时间：
1995-04-01
影响因子：
3.5
通讯作者：
QUINN, N
中科院分区：
文献类型：
--
作者：
WENNING, GK;SHEPHARD, B;QUINN, N
特发性帕金森病（IPD）患者的嗅觉明显受损。这一缺陷与非典型帕金森综合征患者的嗅觉保留或仅轻度降低的报道形成对比。然而，嗅觉功能测试在帕金森综合征鉴别诊断中的敏感性和特异性尚未研究。此外，皮质基底节变性（CBD）患者的嗅觉功能尚不清楚。材料和方法-使用宾夕法尼亚大学嗅觉识别测试（UPSIT），测试分数范围从0到40，我们研究了IPD患者的嗅觉功能以及其他帕金森综合征，包括CBD和进行性核上性麻痹（PSP）。结果：118例IPD患者、29例MSA患者、15例PSP患者和7例CBD患者的UPSIT评分相同。在123名健康对照受试者中，与MSA患者的轻度损伤和PSP和CBD患者的正常嗅觉相比，IPD组显示出明显的损伤。UPSIT评分为25/40时，区分IPD和非典型帕金森综合征的敏感性为77%，特异性为85%。结论：这些结果表明，嗅觉功能在不同的帕金森综合征中是不同的受损或保留的，它也可能作为诊断指标具有一定的价值。因此，帕金森病患者的嗅觉功能保留或轻度受损更可能与非典型帕金森病（如MSA、PSP或CBD）有关，而嗅觉明显降低更可能提示IPD。
Introduction - Olfaction is markedly impaired in patients with idiopathic Parkinson's disease (IPD). This deficit contrasts with reports of preserved or only mildly reduced olfaction in patients with atypical parkinsonism. However, the sensitivity and specificity of olfactory function testing in the differential diagnosis of parkinsonian syndromes has not been studied. In addition, olfactory function in patients with corticobasal degeneration (CBD) is unknown. Material and methods - Using the University of Pennsylvania Smell Identification Test (UPSIT) with a test score ranging from 0 to 40 we studied olfactory function in patients with IPD as well as other parkinsonian syndromes including CBD and progressive supranuclear palsy (PSP). Results - UPSIT scores in 118 patients with IPD, 29 with MSA, 15 with PSP, and 7 patients with CBD, as well. as in 123 healthy control subjects revealed a marked impairment in the IPD group in contrast to mild impairment in MSA patients and normal olfaction in PSP and CBD patients. An UPSIT score of 25/40 was associated with a sensitivity of 77% and a specificity of 85% in differentiating IPD from atypical parkinsonism. Conclusions - These results indicate that olfactory function is differentially impaired or preserved in distinct parkinsonian syndromes and that it might also have some value as a diagnostic pointer. Thus, preserved or mildly impaired olfactory function in a parkinsonian patient is more likely to be related to atypical parkinsonism such as MSA, PSP or CBD, whereas markedly reduced olfaction is more suggestive of IPD.