The effect of injection of EGb 761 into the lateral ventricle on hippocampal cell apoptosis and stem cell stimulation in situ of the ischemic/reperfusion rat model
The effect of injection of EGb 761 into the lateral ventricle on hippocampal cell apoptosis and stem cell stimulation in situ of the ischemic/reperfusion rat model
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DOI：
10.1016/j.neulet.2013.09.015
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发表时间：
2013-10
影响因子：
2.5
通讯作者：
Lingzhi Sun;Weiduan Zhuang;Xiangqing Xu;Jun Yang;Jing Teng;Fengxia Zhang
中科院分区：
文献类型：
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作者：
Lingzhi Sun;Weiduan Zhuang;Xiangqing Xu;Jun Yang;Jing Teng;Fengxia Zhang
EGb 761是流行的和标准化的天然提取物银杏叶的主要活性成分，已知其有益于缺血性中风。在这项研究中，我们探讨了潜在的神经保护作用EGb 761对海马缺血/再灌注大鼠模型。与溶剂给药组相比，EGb 761给药组观察到运动功能显著恢复。1%氯化三苯基四氮唑（TTC）染色显示海马体积明显减小，同时海马神经元凋亡明显减少，细胞增殖和迁移明显增加。本研究报告了EGb 761在中风动物中的治疗潜力，这可能与细胞凋亡的衰减和神经发生的增强有关。
EGb 761 is main active ingredient of the popular and standardized natural extract Ginkgo biloba, which is known to benefit ischemic stroke. In this study we investigated the potential neuroprotective effect of EGb 761 on the hippocampus in the ischemic/reperfusion rat model. Significant recovery of motor function was seen in EGb 761 treated group compared to vehicle treated group. Infarct volume, as revealed by 1% 2,3,5-triphenyltetrazolium chloride (TTC) staining, was significantly reduced, coupled with conspicuous suppression of neurons apoptosis and significant increments in the cell proliferation and migration in hippocampus. This study reports the therapeutic potential of EGb 761 in stroke animals, which could be related to the attenuation of apoptosis and enhancement of neurogenesis.