Regulation of locomotor speed and selection of active sets of neurons by V1 neurons
Regulation of locomotor speed and selection of active sets of neurons by V1 neurons
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DOI：
10.1038/s41467-019-09871-x
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发表时间：
2019-05-22
影响因子：
16.6
通讯作者：
Higashijima, Shin-ichi
中科院分区：
文献类型：
--
作者：
Kimura, Yukiko;Higashijima, Shin-ichi
在脊椎动物的快速运动中，由于肌肉收缩的机械需求，慢运动单位被认为是失活的，但与此相关的神经机制尚不清楚。在这里，我们通过选择性地杀死斑马鱼幼体中的脊髓V1神经元来进行功能分析，揭示了V1神经元的两个功能。第一个是V1神经元长期以来一直被认为的作用：它们通过提供同相抑制，在缩短游泳周期方面发挥着重要作用。第二，V1神经元在神经元活动集的选择中起着重要作用。我们表明，来自V1神经元的强抑制输入在抑制慢型V2a和运动神经元的活动方面发挥了关键作用，从而抑制了快游泳过程中慢肌的活动。因此，我们的结果强调了脊髓抑制神经元在快速运动中抑制慢成分神经元的关键作用。
During fast movements in vertebrates, slow motor units are thought to be deactivated due to the mechanical demands of muscle contraction, but the associated neuronal mechanisms for this are unknown. Here, we perform functional analyses of spinal V1 neurons by selectively killing them in larval zebrafish, revealing two functions of V1 neurons. The first is the long-proposed role of V1 neurons: they play an important role in shortening the cycle period during swimming by providing in-phase inhibition. The second is that V1 neurons play an important role in the selection of active sets of neurons. We show that strong inhibitory inputs coming from V1 neurons play a crucial role in suppressing the activities of slow-type V2a and motor neurons, and, consequently, of slow muscles during fast swimming. Our results thus highlight the critical role of spinal inhibitory neurons for silencing slow-component neurons during fast movements.