Neural mechanisms of autonomic, affective, and cognitive integration
Neural mechanisms of autonomic, affective, and cognitive integration
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DOI：
10.1002/cne.20749
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发表时间：
2005-12-05
影响因子：
2.5
通讯作者：
Critchley, HD
中科院分区：
文献类型：
--
作者：
Critchley, HD
有影响力的理论模型提出了来自身体的传入信息在情绪感受状态表达中的核心作用。身体唤醒状态变化的反馈表征会影响学习并促进并发和前瞻性决策。功能性神经影像学研究加深了人们对行为过程中自主神经唤醒变化的大脑机制以及对内部反馈信号做出反应以影响主观感觉状态的大脑机制的理解。特别是，前扣带皮层与自主神经变化的产生有关，而岛叶和眶额皮质可能专门负责绘制内脏反应。独立地，腹内侧前额叶皮层被认为支持内部（自我）参考过程，该过程在休息和脱离状态下占主导地位，并且被认为是与环境动态交互的基准。病变数据进一步强调了这些皮质区域在自主和动机控制中的综合作用。在控制计算模型中，提出了前向（效果副本）和逆向模型，以实现对行为的预测和纠正，并进一步解释其他人的行为。据推测，动机和情感行为过程中这些过程的神经基础在于前扣带回、岛叶和眶额皮质的相互作用。控制的内脏自主相关性的产生增强了模拟模型中的体验参与，并支撑了诸如躯体标记等概念，以弥合二元鸿沟。
Influential theoretical models propose a central role for afferent information from the body in the expression of emotional feeling states. Feedback representations of changing states of bodily arousal influence learning and facilitate concurrent and prospective decision-making. Functional neuroimaging studies have increased understanding of brain mechanisms that generate changes in autonomic arousal during behavior and those which respond to internal feedback signals to influence subjective feeling states. In particular, anterior cingulate cortex is implicated in generating autonomic changes, while insula and orbitofrontal cortices may be specialized in mapping visceral responses. Independently, ventromedial prefrontal cortex is recognized to support processes of internal (self-) reference that predominate in states of rest and disengagement and which putatively serve as a benchmark for dynamic interactions with the environment. Lesion data further highlight the integrated role of these cortical regions in autonomic and motivational control. In computational models of control, forward (efference copies) and inverse models are proposed to enable prediction and correction of action and, by extension, the interpretation of the behavior of others. It is hypothesized that the neural substrate for these processes during motivational and affective behavior lies within the interactions of anterior cingulate, insula, and orbitofrontal cortices. Generation of visceral autonomic correlates of control reinforce experiential engagement in simulatory models and underpin concepts such as somatic markers to bridge the dualistic divide.