EXPERIMENTAL MYOCARDIAL-INFARCTION .9. EFFICACY OF HYPERBARIC OXYGENATION IN VENTRICULAR FAILURE AFTER CORONARY OCCLUSION IN INTACT CONSCIOUS DOGS
EXPERIMENTAL MYOCARDIAL-INFARCTION .9. EFFICACY OF HYPERBARIC OXYGENATION IN VENTRICULAR FAILURE AFTER CORONARY OCCLUSION IN INTACT CONSCIOUS DOGS
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DOI：
10.1016/0002-9149(73)90265-8
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发表时间：
1973-01-01
影响因子：
2.8
通讯作者：
HOOD, WB
中科院分区：
文献类型：
--
作者：
GILMOUR, DP;KUMAR, R;HOOD, WB
在这项关于高压氧治疗实验性心肌梗死后左心室衰竭的疗效的研究中，6 只完整的狗接受了 20 分钟的控制期，在 3 个大气压绝对压力下暴露于 100% 的氧气。该手术使动脉 PO2 增加至 1,600 mm Hg 以上，平均主动脉压增加 8% (0.05 <P< 0.10)；左心室舒张末压从8.0毫米汞柱增加至9.7毫米汞柱（P<0.05），而心率、心输出量、每搏输出量、左心室每分钟做功、每搏做功或总外周阻力没有变化。一小时后，发生冠状动脉闭塞并导致左心室衰竭，表现为心率和左心室舒张末压增加以及每搏输出量和每搏功下降。封堵后十分钟，狗经历了第二次高压暴露期，平均主动脉压增加了 9% (0.05 <P< 0.10)，左心室每分钟做功增加了 9% (P< 0.01)，每搏做功增加了 17% (0.05 <P< 0.10)。做功的增加是以左心室舒张末压从 13.1 毫米汞柱增加到 17.4 毫米汞柱为代价的（P<0.01）。其他变量保持稳定。另外8只在呼吸室内空气时接受冠状动脉闭塞的狗在接下来的一小时内具有稳定的血流动力学值，除了左心室舒张末压逐渐增加。结论是，即使是在缺血性病变可能可逆的情况下进行高压氧治疗，也不能改善清醒状态下的完好狗因实验性心肌梗塞而受损的左心室功能。
In this study of the efficacy of hyperbaric oxygenation in the therapy of left ventricular failure after experimental myocardial infarction, 6 intact dogs underwent a 20 minute control period of exposure to 100 percent oxygen at 3 atmospheres absolute of pressure. The procedure increased arterial PO2to more than 1,600 mm Hg and mean aortic pressure by 8 percent (0.05 <P< 0.10); left ventricular end-diastolic pressure increased from 8.0 to 9.7 mm Hg (P< 0.05) without change in heart rate, cardiac output, stroke volume, left ventricular minute work, stroke work or total peripheral resistance. One hour later, coronary occlusion was produced and resulted in left ventricular failure, manifested by an increase in heart rate and left ventricular end-diastolic pressure and by a fall in stroke volume and stroke work. Ten minutes after occlusion, the dogs underwent a second hyperbaric exposure period, and mean aortic pressure increased by 9 percent (0.05 <P< 0.10), left ventricular minute work by 9 percent (P< 0.01) and stroke work by 17 percent (0.05 <P< 0.10). The increased work was performed at the expense of an increase in left ventricular end-diastolic pressure from 13.1 to 17.4 mm Hg (P< 0.01). Other variables remained stable. An additional 8 dogs that underwent coronary occlusion while breathing room air had stable hemodynamic values over the ensuing hour except for a progressive increase in left ventricular end-diastolic pressure. It is concluded that hyperbaric oxygenation did not improve left ventricular function impaired by experimental myocardial infarction in intact, conscious dogs, even though given at a time when the ischemic lesion was potentially reversible.