The Systems Biology Graphical Notation
The Systems Biology Graphical Notation
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DOI：
10.1038/nbt.1558
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发表时间：
2009-08-01
影响因子：
46.9
通讯作者：
Kitano, Hiroaki
中科院分区：
文献类型：
--
作者：
Le Novere, Nicolas;Hucka, Michael;Kitano, Hiroaki
电路图和统一建模语言图只是标准可视化语言的两个例子，它们通过促进规律性、消除歧义和使软件工具支持复杂信息的交流来帮助加快工作。具有讽刺意味的是，尽管拥有图形与文本信息的最高比例之一，生物学仍然缺乏标准的图形符号。最近生物知识的泛滥使得解决这一缺陷成为一个紧迫的问题。为了实现这一目标，我们提出了系统生物学图形符号（SBGN），这是一种由生物化学家、建模师和计算机科学家组成的社区开发的视觉语言。SBGN由三种互补的语言组成：过程图、实体关系图和活动流程图。它们共同使科学家能够以一种标准的、明确的方式表示生化相互作用的网络。我们相信，SBGN将促进从基因调控、代谢到细胞信号等各种生物知识信息的高效、准确的表达、可视化、存储、交换和重用。
Circuit diagrams and Unified Modeling Language diagrams are just two examples of standard visual languages that help accelerate work by promoting regularity, removing ambiguity and enabling software tool support for communication of complex information. Ironically, despite having one of the highest ratios of graphical to textual information, biology still lacks standard graphical notations. The recent deluge of biological knowledge makes addressing this deficit a pressing concern. Toward this goal, we present the Systems Biology Graphical Notation (SBGN), a visual language developed by a community of biochemists, modelers and computer scientists. SBGN consists of three complementary languages: process diagram, entity relationship diagram and activity flow diagram. Together they enable scientists to represent networks of biochemical interactions in a standard, unambiguous way. We believe that SBGN will foster efficient and accurate representation, visualization, storage, exchange and reuse of information on all kinds of biological knowledge, from gene regulation, to metabolism, to cellular signaling.