Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly.
Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly.
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DOI：
10.1016/j.trsl.2020.03.002
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Stout-Delgado HW
中科院分区：
文献类型：
--
作者：
Lee SF;Harris R;Stout-Delgado HW
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Community acquired pneumonia is a leading cause of mortality in the United States. Along with predisposing comorbid health status, age is an independent risk factor for determining the outcome of pneumonia. Research over the last few decades has contributed to better understanding the underlying immunodysregulation and imbalanced redox homeostasis tied to this aged population group that increases susceptibility to a wide range of pathologies. Major approaches include targeting oxidative stress by reducing ROS generation at its main sources of production which includes the mitochondrion. Mitochondria-targeted antioxidants have a number of molecular strategies that include targeting the biophysical properties of mitochondria, mitochondrial localization of catalytic enzymes, and mitigating mitochondrial membrane potential. Results of several antioxidant studies both in vitro and in vivo have demonstrated promising potential as a therapeutic in the treatment of pneumonia in the elderly. More human studies will need to be conducted to evaluate its efficacy in this clinical setting.
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DOI：
10.4049/jimmunol.1100381
发表时间：
2011-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fang R;Tsuchiya K;Kawamura I;Shen Y;Hara H;Sakai S;Yamamoto T;Fernandes-Alnemri T;Yang R;Hernandez-Cuellar E;Dewamitta SR;Xu Y;Qu H;Alnemri ES;Mitsuyama M
通讯作者：
Mitsuyama M
影响因子：
4
作者：
Camara AKS;Zhou Y;Wen PC;Tajkhorshid E;Kwok WM
通讯作者：
Kwok WM
影响因子：
0.4
作者：
Farazi A;Sofian M;Jabbariasl M;Nayebzadeh B
通讯作者：
Nayebzadeh B
影响因子：
4.2
作者：
Babizhayev, Mark A.;Deyev, Anatoly I.
通讯作者：
Deyev, Anatoly I.
线粒体通透性转换孔和氧化还原信号的双重调节协同促进心肌细胞从多能干细胞分化。
影响因子：
5.4
作者：
Cho SW;Park JS;Heo HJ;Park SW;Song S;Kim I;Han YM;Yamashita JK;Youm JB;Han J;Koh GY
通讯作者：
Koh GY