New sesquiterpenoids from the root of Guatteria multivenia.
New sesquiterpenoids from the root of Guatteria multivenia.
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DOI：
10.1021/np0200717
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发表时间：
2002-05
影响因子：
5.1
通讯作者：
Zhizhen Zhang;H. Elsohly;M. Jacob;D. Pasco;L. Walker;A. Clark
中科院分区：
文献类型：
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作者：
Zhizhen Zhang;H. Elsohly;M. Jacob;D. Pasco;L. Walker;A. Clark
用植物化学方法研究了多叶藤根乙醇提取物中的CHCl(3)组分，得到9个化合物，其中4个为倍半萜(1-4)，5个为生物碱(5-9)。其中两个为新化合物(1，3)，命名为Gatterin A(1)和二氢马多林-K(3)，另两个为已知的(2，4)，鉴定为马多林-K(2)和马多林-W(4)。已知的5种生物碱分别鉴定为三七烯碱(5)、赖西胺(6)、羊毛肌苷(7)、愈创木酚(8)和O-甲基苍耳碱(9)。所有已知化合物均为首次从该种中分离得到。新化合物的结构通过广泛的核磁共振研究确定，包括DEPT，COSY，HMQC，HMBC和NOESY。化合物7对白色念珠菌分泌天冬氨酸蛋白酶(SAP)的抑制作用较弱，IC(50)为45微克/毫升。化合物5对白色念珠菌、新型隐球菌、金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌(MRS)具有一定的抗菌活性，其IC(50)/MIC值分别为3.5/6.25、2.0/12.5、2.0/3.13和2.0/3.13微克/毫升。
A phytochemical investigation of the CHCl(3) fraction of an ethanol extract of the root of Guatteria multivenia furnished nine compounds, of which four are sesquiterpenes (1-4) and five are alkaloids (5-9). Of the four sesquiterpenes, two are new (1, 3), named guatterin A (1) and dihydromadolin-K (3), and two are known (2, 4), identified as madolin-K (2) and madolin-W (4). The five known alkaloids were identified as liriodenine (5), lysicamine (6), lanuginosine (7), guadiscine (8), and O-methylpallidine (9). All the known compounds were isolated from this species for the first time. Structures of the new compounds were determined by extensive NMR studies, including DEPT, COSY, HMQC, HMBC, and NOESY. Compound 7 showed weak inhibitory effect against Candida albicans secreted aspartic proteases (SAP) with IC(50) of 45 microg/mL. Compound 5 was found to have antimicrobial activity against C. albicans, Cryptococcusneoformans, Staphylococcus aureus, and methicillin-resistant S. aureus (MRS) with IC(50)/MIC values of 3.5/6.25, 2.0/12.5, 2.0/3.13, and 2.0/3.13 microg/mL, respectively.