Correlates of health-related quality of life in primary caregivers of perinatally HIV infected and HIV exposed uninfected adolescents at the Kenyan Coast.
Correlates of health-related quality of life in primary caregivers of perinatally HIV infected and HIV exposed uninfected adolescents at the Kenyan Coast.
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DOI：
10.1186/s12955-022-01915-z
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发表时间：
2022-01-21
影响因子：
3.6
通讯作者：
Abubakar A
中科院分区：
文献类型：
--
作者：
Mwangala PN;Ssewanyana D;Mwangi P;Chongwo E;Nasambu C;Kagonya VA;Scerif G;Newton CR;Abubakar A
在撒哈拉以南非洲，母亲和其他初级照料者在照料围产期感染艾滋病毒和暴露于艾滋病毒的未感染青少年方面发挥着至关重要的作用。在有限的工具支持和增加的生物医学风险（艾滋病毒血清阳性）的背景下，日常护理可能使这些护理人员暴露于不利的健康状态。不幸的是，很少有研究调查他们的健康相关生活质量（HRQoL）。我们的研究记录了肯尼亚海岸12-17岁围产期艾滋病毒感染、围产期艾滋病毒暴露但未感染和艾滋病毒暴露/未感染青少年的主要照顾者的HRQoL概况及其相关因素。这是一项对485名主要照顾者的横断面分析：195名围产期艾滋病毒感染的青少年，128名围产期艾滋病毒暴露但未感染的青少年和162名未暴露/未感染艾滋病毒的青少年。所有照顾者都完成了HRQoL（有8个分量表）、抑郁症状和育儿压力的自我报告测量。他们还提供了自己和接受护理者的社会人口统计信息。我们使用单因素方差分析来评估组间的统计学差异。采用线性回归分析确定HRQoL的相关因素。总体而言，在总体HRQoL领域和大多数子量表中，未暴露/未感染艾滋病毒的青少年的照顾者报告的平均HRQoL得分明显高于其他照顾者。艾滋病毒暴露青少年的照顾者在总体HRQoL得分和大多数亚量表上没有统计学差异。整个样本的线性回归分析表明，抑郁症状、照顾者年龄的增加以及对围产期暴露于艾滋病毒的青少年的照顾与总体和亚量表水平上的HRQoL降低显著相关。相对于自给农业而言，拥有一份专业工作是改善总体HRQoL的唯一因素。在亚量表水平上，较高的社会经济地位与HRQoL呈正相关，祖父母身份、受教育水平、养育压力与HRQoL呈负相关。这一样本中的照料者，特别是那些上了年纪、有精神疾病风险以及照料围产期感染艾滋病毒的青少年的照料者，似乎容易受到生活质量低下的影响。针对照顾者的社会心理和精神需求量身定制的包容性和多成分干预措施将有可能提高他们的生活质量。在线版本包含补充材料，可在10.1186/s12955-022-01915-z获得。
Mothers and other primary caregivers play a crucial role in looking after perinatally HIV infected, and HIV exposed uninfected adolescents in sub-Saharan Africa. Day- to-day caregiving in the context of limited instrumental support and added biomedical risk (HIV seropositivity) may expose these caregivers to adverse states of health. Unfortunately, very few studies have examined their health-related quality of life (HRQoL). Our study documents the HRQoL profile, and associated factors in primary caregivers of perinatally HIV infected, perinatally HIV exposed but uninfected and HIV unexposed/uninfected adolescents aged 12–17 years at the Kenyan Coast. This was a cross-sectional analysis of 485 primary caregivers: 195 of perinatally HIV infected adolescents, 128 of perinatally HIV exposed but uninfected adolescents and 162 of HIV unexposed/uninfected adolescents. All caregivers completed a self-report measure of HRQoL (having 8 subscales), depressive symptoms, and parenting stress. They also provided their sociodemographic information and that of the care recipients. We used one-way analysis of variance to assess statistical differences among the groups. Linear regression analyses were used to identify correlates of HRQoL. Overall, caregivers of HIV unexposed/uninfected adolescents reported significantly higher mean HRQoL scores than the other caregivers in the overall HRQoL domain and majority of the subscales. There were no statistical differences in the overall HRQoL scores and most subscales between caregivers of HIV exposed adolescents. Linear regression analyses across the sample indicated that depressive symptoms, increasing age of caregiver, and caring for an adolescent perinatally exposed to HIV were significantly associated with reduced HRQoL at both the overall and sub-scale level. Having a professional job relative to subsistence farming was the only factor associated with improved overall HRQoL. At subscale level, higher socioeconomic status correlated positively with HRQoL while being a grandparent, level of education, parenting stress were negatively associated with HRQoL. Caregivers in this sample, especially those who are ageing, at risk of mental ill-health, and taking care of adolescents perinatally exposed to HIV, appear to be vulnerable to poor quality of life. Inclusive and multi-component interventions tailored to the caregivers' psychosocial and mental needs will potentially enhance their quality of life. The online version contains supplementary material available at 10.1186/s12955-022-01915-z.
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影响因子：
2.5
作者：
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