Intravenous levetiracetam in children with epilepsy
Intravenous levetiracetam in children with epilepsy
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DOI：
10.1016/j.pediatrneurol.2007.11.003
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发表时间：
2008-03-01
影响因子：
3.8
通讯作者：
Kothare, Sanjeev V.
中科院分区：
文献类型：
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作者：
Goraya, Jatinder S.;Khurana, Divya S.;Kothare, Sanjeev V.
静脉注射左乙拉西坦最近可用于年龄> 16岁的患者。关于其在儿童中的安全性和有效性的数据很少。我们回顾性分析了静脉注射左乙拉西坦治疗儿童的数据。10例患者（6例女性，4例男性），年龄3周至19岁，接受左乙拉西坦静脉给药，平均剂量为50.5 mg/kg/天，平均持续时间为4.9天。4例患者接受左乙拉西坦静脉给药治疗急性反复发作/癫痫持续状态，3例患者因口服左乙拉西坦暂时不可行而替代口服左乙拉西坦。各有1例患者在脑活检期间接受左乙拉西坦静脉注射预防癫痫发作，在急性癫痫发作后接受左乙拉西坦维持治疗，并作为丙戊酸钠的替代品。4例急性重复性癫痫发作/癫痫持续状态患者中有3例无癫痫发作;第4例患者癫痫发作频率部分降低。所有三名接受静脉注射左乙拉西坦替代口服左乙拉西坦的患者对转换耐受良好。其他3例患者静脉注射左乙拉西坦后无并发症。没有观察到严重的不良反应，所有患者都完成了预定时间段的左乙拉西坦静脉给药治疗。静脉注射左乙拉西坦在需要静脉注射抗癫痫药物的各种临床情况下可能有效。(C)2008年，Elsevier Inc. All rights reserved.
Intravenous levetiracetam recently became available for use in patients aged > 16 years. There are few data about its safety and efficacy in children. We retrospectively analyzed data from children treated with intravenous levetiracetam. Ten patients (6 female, 4 male), aged 3 weeks to 19 years, were treated with intravenous levetiracetam at a mean dose of 50.5 mg/kg/day for a mean duration of 4.9 days. Four patients received intravenous levetiracetam for acute repetitive seizures/status epilepticus, and three as replacement for oral levetiracetam because administration of oral levetiracetam was temporarily infeasible. One patient each received intravenous levetiracetam for seizure prophylaxis during brain biopsy, as maintenance treatment after acute seizures, and as substitute for sodium valproate. Three of four patients with acute repetitive seizures/status epilepticus became seizure-free; the fourth patient had a partial reduction in seizure frequency. All three patients who received intravenous levetiracetam as substitute for oral levetiracetam tolerated the switch well. The other three patients were seizure-free on intravenous levetiracetam. No serious adverse effects were observed, and all patients completed treatment with intravenous levetiracetam for the intended period. Intravenous levetiracetam may be effective in various clinical situations requiring intravenous administration of an antiepileptic drug. (C) 2008 by Elsevier Inc. All rights reserved.