BIFIDOBACTERIA AND PROBIOTIC EFFECTS - ACTION OF BIFIDOBACTERIUM SPECIES ON CONJUGATED BILE-SALTS
BIFIDOBACTERIA AND PROBIOTIC EFFECTS - ACTION OF BIFIDOBACTERIUM SPECIES ON CONJUGATED BILE-SALTS
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DOI：
10.1007/bf00294629
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发表时间：
1995-07-01
影响因子：
2.6
通讯作者：
BALLONGUE, J
中科院分区：
文献类型：
--
作者：
GRILL, JP;MANGINOTDURR, C;BALLONGUE, J
研究了六种不同的结合胆汁盐（两种三羟基结合胆汁盐：牛磺和甘氨胆酸；以及四种二羟基结合胆盐：牛磺和甘氨鹅脱氧胆酸、牛磺和甘氨脱氧胆酸）对八种双歧杆菌菌株的影响。每种胆汁盐和菌株均观察到强烈的生长抑制作用（0.95 mM 时为 80%）。这种现象可以通过双歧杆菌生长过程中产生去结合胆汁盐来解释。解结合现象与生物质生产同时发生，解结合胆汁盐是双歧杆菌生物转化过程中产生的唯一化合物。在静息细胞实验中，菌株和胆汁盐种类之间出现差异，特别是牛磺胆酸。长双歧杆菌菌株是测试的细菌中最有效的。
The effect of six different conjugated bile salts (two trihydroxyconjugated bile salts: tauro and glycocholic acids; and four dihydroxyconjugated bile salts: tauro- and glycochenodeoxycholic, tauro- and glycodeoxycholic acids) on eight bifidobacteria strains were studied. A strong growth-inhibitory effect was observed (80% at 0.95 mM) for each bile salt and strain. This phenomenon was explained by the production of deconjugated bile salt during bifidobacteria growth. The deconjugation phenomenon was concurrent with biomass production, and deconjugated bile salts were the sole compound produced during bifidobacteria biotransformation. In resting cell experiments, differences appeared between the strains and the kind of bile salts, particularly concerning taurocholic acid. The Bifidobacterium longum strains were the most efficient among the bacteria tested.