Biomaterial microarrays: rapid, microscale screening of polymer-cell interaction
Biomaterial microarrays: rapid, microscale screening of polymer-cell interaction
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DOI：
10.1016/j.biomaterials.2004.11.052
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发表时间：
2005-08-01
期刊：
影响因子：
14
通讯作者：
Langer, R
中科院分区：
文献类型：
--
作者：
Anderson, DG;Putnam, D;Langer, R
诱导最佳基因表达模式并允许适当水平的细胞附着的生物材料的鉴定在组织工程和细胞治疗中是至关重要的。在这里，我们描述了创建细胞相容的生物材料微阵列，允许快速，微尺度测试生物材料与细胞的相互作用。作为原理的证明，我们同时表征了超过3456个人间充质干细胞（hMSC）-生物材料复合物相互作用，并描述了这些阵列与神经干细胞系（NSC）和初级关节软骨细胞的效用的初步研究。(C)2004爱思唯尔有限公司保留所有权利。
The identification of biomaterials that induce optimal gene expression patterns and allow for appropriate levels of cellular attachment is of central importance in tissue engineering and cell therapy. Herein, we describe the creation of cell-compatible, biomaterial microarrays, that allow rapid, microscale testing of biomaterial interactions with cells. As proof of principle, we simultaneously characterized over 3456 human mesenchymal stem cell (hMSC)-biomaterial composite interactions, and describe preliminary studies on the utility of these arrays with a neural stem cell line (NSC), and primary articular chondrocytes. (C) 2004 Elsevier Ltd. All rights reserved.