Biological roles of uterine glands in pregnancy.
Biological roles of uterine glands in pregnancy.
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DOI：
10.1055/s-0034-1376354
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发表时间：
2014-09
影响因子：
2.7
通讯作者：
Spencer TE
中科院分区：
文献类型：
--
作者：
Spencer TE
所有哺乳动物的子宫都在子宫内膜中含有腺体，这些腺体合成或运输和分泌对孕体（胚胎/胎儿和相关的胚外膜）生存和发育至关重要的物质。本综述总结了与子宫腺体及其分泌物在人类和动物模型中囊胚/概念存活和着床、子宫容受性以及基质细胞蜕膜化中的生物学作用相关的信息。在绵羊子宫腺体敲除（UGKO）模型中观察到的不孕症和复发性妊娠丢失明确支持了子宫腺体的主要作用，并由此推断，子宫腔液中存在的子宫腺体分泌物在孕胎的生存和发育中发挥着主要作用。此外，对突变体和孕酮诱导的 UGKO 小鼠的研究发现，子宫腺体及其分泌物是建立子宫容受性、囊胚植入以及基质细胞蜕膜化所必需的。同样，在人类中，子宫腺体及其分泌产物可能是妊娠早期囊胚着床、子宫容受性以及孕体生长和发育的关键调节因子。间接证据表明，腺体活动不足可能是人类妊娠失败和并发症的一个致病因素。因此，加深对子宫腺生物学的了解对于诊断、预防和治疗哺乳动物的生育和妊娠问题非常重要。
All mammalian uteri contain glands in the endometrium that synthesize or transport and secrete substances essential for survival and development of the conceptus (embryo/fetus and associated extraembryonic membranes). This review summarizes information related to the biological roles of uterine glands and their secretions in blastocyst/conceptus survival and implantation, uterine receptivity, and stromal cell decidualization in humans and animal models. The infertility and recurrent pregnancy loss observed in the ovine uterine gland knockout (UGKO) model unequivocally supports a primary role for uterine glands and, by inference, their secretions present in uterine luminal fluid in survival and development of the conceptus. Further, studies with mutant and progesterone-induced UGKO mice found that uterine glands and their secretions are required for establishment of uterine receptivity and blastocyst implantation as well as stromal cell decidualization. Similarly in humans, uterine glands and their secretory products are likely critical regulators of blastocyst implantation, uterine receptivity, and conceptus growth and development during the first trimester. Circumstantial evidence suggests that deficient glandular activity may be a causative factor in pregnancy failure and complications in humans. Thus, an increased understanding of uterine gland biology is important for diagnosis, prevention and treatment of fertility and pregnancy problems in mammals.
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影响因子：
3.5
作者：
Chakraborty, I;Das, SK;Dey, SK
通讯作者：
Dey, SK
影响因子：
82.9
作者：
Cha J;Sun X;Dey SK
通讯作者：
Dey SK
DOI：
10.1073/pnas.0905523106
发表时间：
2009-10-13
影响因子：
11.1
作者：
Arnaud, Estelle;Zenker, Jennifer;Chrast, Roman
通讯作者：
Chrast, Roman
影响因子：
3
作者：
Clausen, BE;Burkhardt, C;Förster, I
通讯作者：
Förster, I
影响因子：
3.3
作者：
BAZER, FW
通讯作者：
BAZER, FW