The action of vasodilating drugs on isolated basilar, coronary and mesenteric arteries of the dog.
The action of vasodilating drugs on isolated basilar, coronary and mesenteric arteries of the dog.
复制标题
血管舒张药物对狗离体基底动脉、冠状动脉和肠系膜动脉的作用。
DOI：
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复制
发表时间：
1974
影响因子：
3.5
通讯作者：
N. Toda
中科院分区：
文献类型：
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作者：
N. Toda
在犬基底动脉、冠状动脉和肠系膜动脉的螺旋条上比较了血管扩张药物的作用。罂粟碱引起剂量依赖性舒张，在这三条动脉中，在10 - 4 M时达到最大舒张。腺苷和亚硝酸钠也产生舒张作用，这些动脉的剂量-反应关系差异很小。在人基底动脉中观察到对腺苷反应的类似松弛。异丙肾上腺素诱导的舒张作用在冠状动脉条中明显大于肠系膜动脉。即使在高浓度下，犬和人的基底动脉松弛也很轻微。乙酰胆碱引起冠状动脉的剂量相关性舒张，阿托品可抑制这种舒张，但普萘洛尔不能抑制这种舒张。在基底动脉，只有轻微的松弛。在肠系膜动脉条中，乙酰胆碱产生双相反应，低浓度时舒张，高浓度时收缩。酚苄明可将收缩逆转为松弛。儿茶酚胺的释放可能参与了乙酰胆碱引起的收缩的发生。似乎就基底动脉而言，肾上腺素能和胆碱能血管扩张机制在血管张力的调节中不起主要作用。
Effects of vasodilating drugs were compared in helical strips of canine basilar, coronary and mesenteric arteries contracted with K + . Papaverine caused a dose-dependent relaxation, the maximum relaxation being attained at 10 -4 M in these three arteries. Adenosine and NaNO 2 , also produced relaxation, and the difference in dose-response relationships in these arteries was only slight. Similar relaxation in response to adenosine was observed in human basilar arteries. Relaxation induced by isoproterenol was appreciably greater in coronary arterial strips than in mesentenic arteries. Relaxation in basilar arteries of dogs and humans was slight even at high concentrations. Acetylcholine elicited a dose-realted relaxation in coronary arteries which was inhibited by treatment with atropine but not by propranolol. In basilar arteries, only a slight relaxation was produced. In mesenteric arterial strips, acetylcholine produced biphasic responses, relaxation at low concentrations and contraction at high concentrations. The contraction was reversed to a relaxation by phenoxybenzamine. The release of catecholamines may be involved in the genesis of the acetylcholine-induced contraction. It appears that as far as basilar arteries are concerned, adrenergic and cholinergic vasodilator mechanisms do not play a major role in the regulation of the vascular tone.