Clinicopathologic and Prognostic Significance of Carboxyl Terminus of Hsp70-interacting Protein in HBV-related Hepatocellular Carcinoma.
Clinicopathologic and Prognostic Significance of Carboxyl Terminus of Hsp70-interacting Protein in HBV-related Hepatocellular Carcinoma.
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DOI：
10.7314/apjcp.2015.16.9.3709
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发表时间：
2015-05
期刊：
影响因子：
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通讯作者：
Ye Jin;Li Zhou;Z. Liang;K. Jin;Weixun Zhou;B. Xing
中科院分区：
文献类型：
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作者：
Ye Jin;Li Zhou;Z. Liang;K. Jin;Weixun Zhou;B. Xing
背景：许多因素，包括分子因素，被证明与肝细胞癌（HCC）的长期预后相关。迄今为止，hsp70相互作用蛋白（CHIP）羧基末端在乙型肝炎病毒（HBV）相关HCC中的表达及其临床病理和预后意义尚不清楚。材料与方法对79例HBsAg阳性HCC手术标本进行免疫组化染色，检测CHIP表达。此外，还评估了与临床病理参数和患者生存率的相关性。结果肿瘤组织CHIP染色阳性，非肿瘤组织CHIP染色阳性。CHIP的高表达与较大的肿瘤大小显著相关，与门静脉侵入和血清a-胎蛋白水平升高的存在轻微显著相关。此外，单变量分析显示，CHIP高表达是总体生存率和无病生存率较低的有力预测因子。然而，在多变量Cox回归试验中，CHIP的独立预后意义尚未得到证实。结论CHIP在hbv相关HCC中过表达，与不良的生物学行为和不良预后相关。然而，其预后作用有待进一步验证。
BACKGROUND Many factors, including molecular ones, were demonstrated to be associated with long-term prognosis of hepatocellular carcinoma (HCC). Thus far, the expression and clinicopathologic and prognostic significance of the carboxyl terminus of Hsp70-interacting protein (CHIP) in B-type hepatitis virus (HBV)- related HCC remain unknown. MATERIALS AND METHODS CHIP expression was detected by immunohistochemical staining of surgical samples from 79 patients with HCC with HBsAg positivity. In addition, correlations with clinicopathologic parameters and patient survival were evaluated. RESULTS It was found that positive CHIP staining was observed in tumor, but not non-tumor, tissues. High expression of CHIP was significantly related to larger tumor size, with marginally significant associations noted for presence of portal vein invasion and higher serum a-fetoprotein level. In addition, univariate analysis showed that high CHIP expression was a powerful predictor for dismal overall and disease-free survival. However, independent prognostic implications of CHIP were not proven in multivariate Cox regression test. CONCLUSIONS CHIP is overexpressed in HBV-related HCC and is associated with unfavorable biological behavior as well as poor prognosis. However, its prognostic role needs to be further validated.