Optical observation of contrast agent destruction
Optical observation of contrast agent destruction
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DOI：
10.1063/1.1287519
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发表时间：
2000-08-14
影响因子：
4
通讯作者：
Ferrara, K
中科院分区：
文献类型：
--
作者：
Chomas, JE;Dayton, PA;Ferrara, K
超声造影剂在微秒时间尺度上的碎裂为微血管检测、血流速度估计和靶向药物递送的进步提供了机会。由高速成像系统捕获的图像显示在压缩期间微泡的破坏。峰值压力为-1.1Mpa、中心频率为2.4 MHz的冲击下，观察到峰值壁速度为-700 m/s，峰值加速度为1.2 x 10（12）m/s（2）。使用改进的Rayleigh-Plesset模型对壁面速度和加速度进行理论计算，预测峰值负壁面速度为-680 m/s，峰值加速度为2 x 10（12）m/s（2）。(C)2000年美国物理学会。【S0003-6951（00）03030-8】。
Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during compression. Peak wall velocity of -700 m/s and peak acceleration of 1.2 x 10(12) m/s(2) is observed for insonation with a peak pressure of -1.1 MPa and a center frequency of 2.4 MHz. Theoretical calculations of wall velocity and acceleration using a modified Rayleigh-Plesset model predict a peak negative wall velocity of -680 m/s and peak acceleration of 2 x 10(12) m/s(2). (C) 2000 American Institute of Physics. [S0003-6951(00)03030-8].