Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.
Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.
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α 和 β 人类转化生长因子刺激培养小鼠颅骨中前列腺素的产生和骨吸收。
DOI：
10.1073/pnas.82.13.4535
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发表时间：
1985
影响因子：
11.1
通讯作者：
Levine,L
中科院分区：
文献类型：
--
作者：
TashjianJr,AH;Voelkel,EF;Lazzaro,M;Singer,FR;Roberts,AB;Derynck,R;Winkler,ME;Levine,L
人α和β转化生长因子（TGF-α和TGF-β）刺激器官培养中新生小鼠颅骨中前列腺素E2（PGE 2）的产生和骨吸收。在0.2 ng/ml（35 pM）浓度下观察到TGF-α对骨吸收的显著刺激，在0.2 ng/ml（8.0 pM）浓度下观察到TGF-β对骨吸收的显著刺激。吲哚美辛可抑制TGF-α或TGF-β刺激的PGE 2生成增加和骨吸收。我们的结论是，TGF-α和TGF-β是强有力的和强大的刺激剂的小鼠骨吸收的机制，涉及增强局部生产的PGE 2。
Human alpha and beta transforming growth factors (TGF-alpha and TGF-beta) stimulated the production of prostaglandin E2 (PGE2) and bone resorption in neonatal mouse calvaria in organ culture. Significant stimulation of bone resorption by TGF-alpha was observed with a concentration of 0.2 ng/ml (35 pM) and by TGF-beta with 0.2 ng/ml (8.0 pM). Enhanced production of PGE2 and bone resorption stimulated by either TGF-alpha or TGF-beta were both inhibited by indomethacin. We conclude that TGF-alpha and TGF-beta are potent and powerful stimulators of the resorption of mouse bone by a mechanism that involves the enhanced local production of PGE2.