RNA-based regulation in type I toxin-antitoxin systems and its implication for bacterial persistence.

RNA-based regulation in type I toxin-antitoxin systems and its implication for bacterial persistence.
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DOI:
10.1007/s00294-017-0710-y
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发表时间:
2017-12
期刊:
影响因子:
2.5
通讯作者:
Wagner EGH
Wagner EGH
中科院分区:
生物学3区
文献类型:
--
作者:
Berghoff BA;Wagner EGH

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细菌休眠是在具有挑战性的环境条件下有价值的生存策略。背细胞耐受高压力水平的后果,并可能在返回到有利条件时重新填充环境。耐抗生素的细菌称为持久性,经常引起复发性感染,增加抗生素耐药性的可能性,因此,赢得越来越多的关注。它们的产生通常依赖于来自染色体毒素-抗毒素系统的毒素。在这里,我们回顾了最近的见解有关RNA为基础的控制毒素的合成,并讨论了可能的影响persister代。
Bacterial dormancy is a valuable survival strategy upon challenging environmental conditions. Dormant cells tolerate the consequences of high stress levels and may re-populate the environment upon return to favorable conditions. Antibiotic-tolerant bacteria—termed persisters—regularly cause relapsing infections, increase the likelihood of antibiotic resistance, and, therefore, earn increasing attention. Their generation often depends on toxins from chromosomal toxin–antitoxin systems. Here, we review recent insights concerning RNA-based control of toxin synthesis, and discuss possible implications for persister generation.
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