Role of exosome-associated adenosine in promoting angiogenesis.
Role of exosome-associated adenosine in promoting angiogenesis.
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DOI：
10.20517/2574-1209.2019.37
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Whiteside, Theresa L
中科院分区：
文献类型：
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作者：
Ludwig, Nils;Jackson, Edwin K;Whiteside, Theresa L
外泌体在不同生理和病理环境中的作用是当前非常感兴趣的新兴领域。外泌体的一个标志是促进血管形成。不同细胞来源的外来体已显示富含直接促进血管生成的血管生成蛋白。此外，外泌体也是腺苷的有效生产者，并可能将腺苷封装在其管腔中。外泌体的腺苷含量与其免疫抑制作用有关。在这篇文章中，我们考虑了肿瘤细胞来源的外泌体产生腺苷的可能性，这可能是一种刺激肿瘤微环境中血管生成的新途径。
The role of exosomes in different physiological and pathological settings is an emerging field of great current interest. One hallmark of exosomes is the promotion of blood vessel formation. Exosomes of different cellular origin have been shown to be enriched in angiogenic proteins which directly promote angiogenesis. In addition, exosomes are also efficacious producers of adenosine and potentially encapsulate adenosine in their lumen. The adenosine content of exosomes has been linked to their immunosuppressive effects. In this communication, we consider the possibility that adenosine production by tumor cell-derived exosomes may represent a novel pathway for stimulation of angiogenesis in the tumor microenvironment.