RNAi-mediated antiviral immunity in insects and their possible application
RNAi-mediated antiviral immunity in insects and their possible application
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DOI：
10.1016/j.coviro.2018.10.004
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发表时间：
2018-10-01
影响因子：
5.9
通讯作者：
Schnettler, Esther
中科院分区：
文献类型：
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作者：
Leggewie, Mayke;Schnettler, Esther
昆虫中的抗病毒RNA干扰（RNAi）已知已有一段时间。以前，来自模式生物果蝇的数据被轻易地转移到其他昆虫身上。然而，由于对其他昆虫进行了更多的研究，揭示了昆虫RNAi途径之间的相似性和重要差异。例如，皮尔纳途径被认为在蚊子中具有抗病毒功能，这在其他昆虫中是未知的。此外，在感染过程中从RNA病毒产生病毒cDNA以及它们可能并入基因组暗示了蚊子中潜在的遗传免疫力。抗病毒RNAi途径的知识增加已经开始努力工程昆虫抵抗病毒感染。基因组编辑的新进展将进一步刺激这一进程。
Antiviral RNA interference (RNAi) in insects is known for some time. Previously, data from the model organism Drosophila was lightly transferred to other insects. However, since more research is performed on other insects, both similarities and important differences among the RNAi pathways of insects are revealed. The piRNA pathway, for example, is suggested to have antiviral functions in mosquitoes, which is unknown for other insects. Moreover, production of viral cDNA from RNA viruses during infection and their possible incorporation into the genome hint towards potential inheritable immunity in mosquitoes. Increased knowledge of antiviral RNAi pathways has initiated efforts to engineer insects resistant to viral infections. New advances in genome editing will further stimulate this process.