The F-like protein Ac23 enhances the infectivity of the budded virus of gp64-null Autographa californica multinucleocapsid nucleopolyhedrovirus pseudotyped with baculovirus envelope fusion protein F
The F-like protein Ac23 enhances the infectivity of the budded virus of gp64-null Autographa californica multinucleocapsid nucleopolyhedrovirus pseudotyped with baculovirus envelope fusion protein F
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F样蛋白Ac23增强杆状病毒包膜融合蛋白F假型gp64缺失苜蓿银纹夜蛾多核衣壳核多角体病毒芽生病毒的感染性
DOI：
10.1128/jvi.00759-08
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发表时间：
2008-10-01
影响因子：
5.4
通讯作者：
Wang, Hualin
中科院分区：
文献类型：
--
作者：
Wang, Manli;Tan, Ying;Wang, Hualin
GP64和F蛋白先前被确定为杆状病毒科中唯一具有功能的包膜融合蛋白。仅存在于I组核多角体病毒（NPV）中的F样蛋白是残余的、无功能的F蛋白。在本报告中，我们描述了在一种用来自甜菜夜蛾多核衣壳核多角体病毒（SeF）的F蛋白假型化的缺失gp64的苜蓿银纹夜蛾多核衣壳核多角体病毒中，F样蛋白Ac23存在与否的影响。我们发现Ac23的存在提高了假型病毒的感染性。这与Lung等人（《病毒学杂志》76:5729 - 5736, 2002）的结果相反，他们没有发现这种影响。对结果不同的可能原因进行了讨论。
The GP64 and F proteins were previously identified as the sole functional envelope fusion proteins in Baculoviridae. F-like proteins, present only in group I nucleopolyhedroviruses (NPVs), are remnant, nonfunctional F proteins. In this report, we describe the effect of the presence or absence of the F-like protein Ac23 in a gp64-null Autographa californica multinucleocapsid NPV pseudotyped with the F protein from Spodoptera exigua multicapsid NPV (SeF). We found that the presence of Ac23 elevates the infectivity of the pseudotyped virus. This is in contrast to the results of Lung et al. (J. Virol. 76:5729-5736, 2002), who found no such effect. The possible reasons for the differing results are discussed.