LIGHT-INDUCED RETINAL DAMAGE USING DIFFERENT LIGHT SOURCES, PROTOCOLS AND RAT STRAINS REVEALS LED PHOTOTOXICITY
LIGHT-INDUCED RETINAL DAMAGE USING DIFFERENT LIGHT SOURCES, PROTOCOLS AND RAT STRAINS REVEALS LED PHOTOTOXICITY
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DOI：
10.1016/j.neuroscience.2016.10.015
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发表时间：
2016-12-17
期刊：
影响因子：
3.3
通讯作者：
Behar-Cohen, F.
中科院分区：
文献类型：
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作者：
Krigel, A.;Berdugo, M.;Behar-Cohen, F.
为了节约能源，欧洲能源使用产品生态设计指令 (2005/32/CE) 建议用更经济的设备（例如发光二极管 (LED)）替代白炽灯。然而，这些设备的发射光谱富含蓝色辐射，已知对视网膜有潜在危险。最近的研究表明，光照会导致年龄相关性黄斑变性 (AMD) 早期的发生。在这里，我们在白化老鼠和色素老鼠中研究了不同暴露方案的影响。将高亮度下的 24 小时暴露与国内水平的循环（暗/亮）暴露 1 周和 1 个月进行比较，使用不同的 LED（冷白光、蓝光和绿光）以及氟紧凑型灯泡和荧光灯管。数据表明，白光 LED 的蓝色成分可能会在职业家庭照度下引起视网膜毒性，而不仅仅是在极端实验条件下，如之前报道的那样。需要注意的是，目前的法规和标准是在急性光照射的基础上制定的，并没有考虑到重复照射的影响。 (C) 2016 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
To save energy, the European directives from the Eco-design of Energy Using Products (2005/32/CE) have recommended the replacement of incandescent lamps by more economic devices such as Light Emitting Diodes (LEDs). However, the emission spectrum of these devices is enriched in blue radiations, known to be potentially dangerous to the retina. Recent studies showed that light exposure contributes to the onset of early stages of age-related macular degeneration (AMD). Here, we investigate, in albinos and pigmented rats, the effects of different exposure protocols. Twenty-four hours exposure at high luminance was compared to a cyclic (dark/light) exposure at domestic levels for 1 week and 1 month, using different LEDs (Cold white, blue and green), as well as fluorocompact bulbs and fluorescent tubes. The data suggest that the blue component of the white-LED may cause retinal toxicity at occupational domestic illuminance and not only in extreme experimental conditions, as previously reported. It is important to note that the current regulations and standards have been established on the basis of acute light exposure and do not take into account the effects of repeated exposure. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.