Regulatory non-coding RNAs: revolutionizing the RNA world
Regulatory non-coding RNAs: revolutionizing the RNA world
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调节性非编码 RNA：彻底改变 RNA 世界
DOI：
10.1007/s11033-014-3259-6
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发表时间：
2014-06-01
影响因子：
2.8
通讯作者：
Zhang, Rongxin
中科院分区：
文献类型：
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作者：
Huang, Biao;Zhang, Rongxin
哺乳动物和其他高等生物的大部分基因组DNA序列可以转录成丰富的功能性RNA转录物，特别是以发育和物种特异性调控方式表达的调控性非编码RNA（ncRNA）。本文综述了各种调控性非编码RNA，包括调控性小非编码RNA（sncRNA）和长非编码RNA（lncRNA），并分别总结了sncRNA和lncRNA的2种和8种不同的作用模式，功能性ncRNA通过这些作用模式介导细胞内事件的调控。
The majority of the genomic DNA sequence in mammalian and other higher organisms can be transcribed into abundant functional RNA transcripts, especially regulatory non-coding RNAs (ncRNAs) that are expressed in a developmentally and species-specific regulated manner. Here, we review various regulatory non-coding RNAs, including regulatory small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs), and summarize two and eight kinds of distinct modes of action for sncRNAs and lncRNAs respectively, by which functional ncRNAs mediate the regulation of intracellular events.