INFLUENCE OF THE AGE OF MICE AT EXPOSURE TO RADIATION ON LIFE-SHORTENING AND CARCINOGENESIS
INFLUENCE OF THE AGE OF MICE AT EXPOSURE TO RADIATION ON LIFE-SHORTENING AND CARCINOGENESIS
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DOI：
10.1269/jrr.32.supplement2_73
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发表时间：
1991-12-01
影响因子：
2
通讯作者：
SASAKI, S
中科院分区：
文献类型：
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作者：
SASAKI, S
雌性B6C3F1小鼠于出生前第17天，出生后第0、7、35、105、240、365天分别接受CS-137照射，剂量分别为0.95、1.9、2.85、3.8、5.7Gy.他们被允许在特定的无病原体条件下度过一生。所有的小鼠都在死亡时进行了尸检，并接受了肿瘤和非肿瘤疾病的组织学检查。出生后早期的小鼠对辐射的缩短寿命最为敏感。胎儿期晚期照射与青壮年照射的缩短率基本相同。胎儿期晚期照射后，小鼠肺、肝、垂体、卵巢、骨肿瘤和淋巴细胞型恶性淋巴瘤的发生率增加。出生后早期的小鼠比胎鼠更容易诱发肝脏和卵巢肿瘤以及淋巴细胞型恶性淋巴瘤。在胎儿期和新生期照射小鼠时，髓系白血病和哈德氏腺肿瘤不会过度发展；而这些肿瘤是在成人期照射诱发的。
Female B6C3F1 mice were irradiated on day 17 prenatal age, or day 0, 7, 35, 105, 240 or 365 postnatal age with 0.95, 1.9, 2.85, 3.8 or 5.7 Gy of gamma-rays from CS-137. They were allowed to live out their entire life spans under specific pathogen free conditions. All the mice were given autopsies at death and were examined histologically for neoplastic and non-neoplastic diseases. The mice in the early postnatal period were most sensitive to the life-shortening effect of radiation. The shortening effect of irradiation given during the late fetal period was almost the same as that given during the young adult period. Incidences of lung, liver, pituitary, ovarian and bone tumors and malignant lymphoma of the lymphocytic type increased after irradiation of mice in the late fetal period. Mice in the early postnatal period are more susceptible to the induction of liver and ovarian tumors and malignant lymphoma of the lymphocytic type than are fetal mice. Myeloid leukemia and Harderian gland tumor did not develop in excess when mice were irradiated in fetal or in neonatal period; whereas, these neoplasms were induced by irradiation during the adult period.