Transient monoclonal expansion of CD8+/CD57+T-cell large granular lymphocytes after primary cytomegalovirus infection
Transient monoclonal expansion of CD8+/CD57+T-cell large granular lymphocytes after primary cytomegalovirus infection
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DOI：
10.1002/ajh.20981
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发表时间：
2007-12-01
影响因子：
12.8
通讯作者：
Gaidano, Gianluca
中科院分区：
文献类型：
--
作者：
Rossi, Davide;Franceschetti, Silvia;Gaidano, Gianluca
与病毒感染相关的淋巴细胞增多通常是多克隆或寡克隆的。在这篇文章中，我们描述了一个短暂的单克隆CD 8 +/CD 57 + T细胞淋巴细胞增多症与大颗粒淋巴细胞（LGL）的形态发生后，原发性CMV感染和审查的情况下，病毒相关的单克隆CD 8 + T细胞扩增的文献报道。病毒相关的单克隆CD 8 + T细胞扩增所共有的几个临床特征表明淋巴细胞增多的反应性。基于此，我们的病例报告和文献报道支持T细胞受体克隆性本身不一定是恶性肿瘤的指标。这些观察结果进一步证实了在将LGL白血病的诊断分配给发生单克隆CD 8 + T细胞扩增的个体之前需要密切随访。Am.J.Hematol.82：1103- 1105，2007. (c)2007Wiley-Liss，Inc.
Lymphocytosis associated with viral infection is generally polyclonal or oligoclonal. In this article, we describe a case of transient monoclonal CD8+/CD57+ T-cell lymphocytosis with large granular lymphocyte (LGL) morphology occurring after primary CMV infection and review cases of virus-associated monoclonal CD8+ T-cell expansions reported in the literature. Several clinical features shared by virus-associated monoclonal CD8+ T-cell expansions suggest the reactive nature of the lymphocytosis. Based on this, our case report and those reported in the literature support the notion that T-cell receptor clonality per se is not necessarily indicative of malignancy. These observations further corroborate the need for a close follow-up before assigning the diagnosis of LGL leukemia to individuals developing monoclonal CD8+ T-cell expansions. Am.J.Hematol.82:1103-1105,2007. (c) 2007Wiley-Liss,inc.