Genome duplication, a trait shared by 22,000 species of ray-finned fish
Genome duplication, a trait shared by 22,000 species of ray-finned fish
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DOI：
10.1101/gr.640303
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发表时间：
2003-03-01
期刊：
影响因子：
7
通讯作者：
Van de Peer, Y
中科院分区：
文献类型：
--
作者：
Taylor, JS;Braasch, I;Van de Peer, Y
通过系统发育树的重建，我们在人、小鼠和鸡中鉴定出49个单拷贝基因，在四倍体非洲爪蛙中鉴定出1~2个拷贝，在斑马鱼中鉴定出2个拷贝。对于这些基因中的22个，两个斑马鱼复制品在河豚(Takifugu Rubripe)中都有同源基因。对于另外20个基因，我们只发现了一个河豚同源基因，但在每一个案例中，它与斑马鱼的一个复制品的亲缘关系都比与另一个复制品的亲缘关系更密切。43对重复基因映射到25个斑马鱼连锁群中的24个，但它们并不是随机分布的；我们确定了斑马鱼基因组的10个重复区域，每个区域包含2到5组平行基因。这些系统发育和同时性数据表明，斑马鱼和河豚的共同祖先，一种产生了类似22,000个物种的鱼，经历了大规模的基因或完全基因组复制事件，河豚失去了斑马鱼保留的许多重复。
Through phylogeny reconstruction we identified 49 genes with a single copy in man, mouse, and chicken, one or two copies in the tetraploid frog Xenopus laevis, and two copies in zebrafish (Danlo rerio). For 22 of these genes, both zebrafish duplicates had orthologs in the pufferfish (Takifugu rubripes). For another 20 of these genes, we found only one pufferfish ortholog but in each case it was more closely related to one of the zebrafish duplicates than to the other. Forty-three pairs of duplicated genes map to 24 of the 25 zebrafish linkage groups but they are not randomly distributed; we identified 10 duplicated regions of the zebrafish genome that each contain between two and five sets of paralogous genes. These phylogeny and synteny data suggest that the common ancestor of zebrafish and pufferfish, a fish that gave rise to similar to22,000 species, experienced a large-scale gene or complete genome duplication event and that the pufferfish has lost many duplicates that the zebrafish has retained.