Brain regional differences in social encounter-induced Fos expression in male and female rats after post-weaning social isolation.
Brain regional differences in social encounter-induced Fos expression in male and female rats after post-weaning social isolation.
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DOI：
10.1016/j.brainres.2015.11.006
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发表时间：
2016-01-01
期刊：
影响因子：
2.9
通讯作者：
Bland ST
中科院分区：
文献类型：
--
作者：
Ahern M;Goodell DJ;Adams J;Bland ST
早期生活中的逆境与许多心理障碍有关，包括情绪和其他障碍，这些障碍可能表现为对社会挑战的不适当或攻击性反应。本研究使用断奶后社会隔离（PSI）的大鼠，早期生活逆境的模型，检查其对暴露于新的社会遭遇产生的Fos蛋白表达的影响。我们之前报道过，在群居对照组（GRP）中观察到的社会遭遇诱导的内侧前额叶皮层Fos表达的增加在经历过PSI的大鼠中减弱。在这里，我们评估了在其他被认为参与情绪调节和社会行为的大脑区域中Fos的表达。从出生后第21天(P)开始，雄性和雌性大鼠在同性群体或隔离（ISO）中饲养4周，并在P49上与一个新的同性同种动物进行一次15分钟的社会接触。采用免疫组织化学方法对前脑16个区域的Fos阳性细胞进行评估。暴露于一种新型的异质物中，以区域和性别特异性的方式增加了GRP大鼠前脑Fos的表达。在许多区域，包括皮质区、丘脑、缰核、齿状回、侧隔和杏仁核基底外侧，这种增加减弱或不存在。在一些地区，雄性饲养的大鼠Fos的增加幅度大于雌性饲养的大鼠。在某些地区，社会交往与Fos呈负相关。早期生活逆境导致的前脑功能减退可能与社会不当行为有关。
Early life adversity has been related to a number of psychological disorders including mood and other disorders that can manifest as inappropriate or aggressive responses to social challenges. The present study used post-weaning social isolation (PSI) in rats, a model of early life adversity, to examine its effects on Fos protein expression produced by exposure to a novel social encounter. We have previously reported that the social encounter-induced increase in Fos expression in the medial prefrontal cortex observed in group-housed controls (GRP) was attenuated in rats that had experienced PSI. Here we assessed Fos expression in other brain regions thought to be involved in emotion regulation and social behavior. Male and female rats were housed in same-sex groups or in isolation (ISO) for 4 weeks beginning on postnatal day (P) 21 and were exposed to a single 15 min social encounter with a novel same-sex conspecific on P49. Fos positive cells were assessed using immunohistochemistry in 16 regions within the forebrain. Exposure to a novel conspecific increased Fos expression in the forebrain of GRP rats in a region- and sex-specific fashion. This increase was blunted or absent in ISO rats within many regions including cortical regions, thalamus, habenula, dentate gyrus, lateral septum, and basolateral amygdala. In several regions, the increase in Fos was greater in male than in female group housed rats. Negative relationships were observed between social interactions and Fos in some regions. Forebrain hypofunction produced by early-life adversity may be involved in socially inappropriate behavior.