Zn2+ release behavior and surface characteristics of Zn/LDPE nanocomposites and ZnO/LDPE nanocomposites in simulated uterine solution
Zn2+ release behavior and surface characteristics of Zn/LDPE nanocomposites and ZnO/LDPE nanocomposites in simulated uterine solution
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Zn/LDPE纳米复合材料和ZnO/LDPE纳米复合材料在模拟子宫溶液中的Zn2释放行为和表面特性
DOI：
10.1007/s10856-008-3467-5
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发表时间：
2008-05
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
为了减少现有含铜宫内节育器的副作用，本研究开发了锌/低密度聚乙烯（Zn/LDPE）纳米复合材料和氧化锌/低密度聚乙烯（ZnO/LDPE）纳米复合材料。研究了纳米复合材料的制备方法以及锌和氧化锌的粒径对复合材料在模拟子宫液中锌（2+）释放的影响。所有的释放曲线都是双相的：初始快速释放相之后是接近零级的释放期。热压成型法制备的纳米复合材料的Zn（2+）释放速率高于热熔挤出法制备的纳米复合材料。与微米复合材料相比，纳米复合材料的Zn（2+）释放速率在前18 d急剧下降，零级释放期开始较早，后期释放速率较高。采用SEM、XRD和EDX等技术对Zn/LDPE和ZnO/LDPE样品在保温200 d后的微观结构进行了表征。结果表明，ZnO/LDPE纳米复合材料的溶解深度约为60 μ m。Zn/LDPE和ZnO/LDPE样品表面形成了大量的孔隙，表明这些孔隙可以为纳米粒子在基体中的溶解提供通道。由ZnO组成的不期望的沉积物仅在Zn/LDPE纳米复合材料的表面上检测到，这可能增加与IUD相关的副作用的风险。可以预期ZnO/LDPE纳米复合材料比Zn/LDPE纳米复合材料更适用于宫内节育器。
To decrease the side effects of the existing copper-bearing intrauterine devices, the zinc/low-density polyethylene (Zn/LDPE) nanocomposite and zinc-oxide/low-density polyethylene (ZnO/LDPE) nanocomposite have been developed in our research for intrauterine devices (IUDs). In this study, the influences of preparation methods of nanocomposites and particle sizes of zinc and zinc oxide on Zn(2+) release from composites incubated in simulated uterine solution were investigated. All release profiles are biphasic: an initial rapid release phase is followed by a near zero-order release period. Zn(2+) release rates of nanocomposites prepared by compressing moulding are higher than those of the nanocomposites prepared by hot-melt extrusing. Compared with Zn(2+) release from the microcomposites, the release profiles of the nanocomposites exhibit a sharp decrease in Zn(2+) release rate in the first 18 days, an early onset of the zero-order release period and a high release rate of Zn(2+) at the later stage. The microstructure of the Zn/LDPE sample and the ZnO/LDPE sample after being incubated for 200 days was characterized by SEM, XRD and EDX techniques. The results show that the dissolution depth of ZnO/LDPE nanocomposite is about 60 mum. Lots of pores were formed on the surface of the Zn/LDPE sample and ZnO/LDPE sample, indicating that these pores can provide channels for the dissolution of nanoparticles in the matrix. The undesirable deposits that are composed of ZnO are only detected on the surface of Zn/LDPE nanocomposite, which may increase the risk of side effects associated with IUDs. It can be expected that ZnO/LDPE nanocomposite is more suitable for IUDs than Zn/LDPE nanocomposite.
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影响因子：
5.8
作者：
C. R. Young;J. J. Koleng-J.;J. Mcginity
通讯作者：
C. R. Young;J. J. Koleng-J.;J. Mcginity
影响因子：
2.9
作者：
K. Hagenfeldt
通讯作者：
K. Hagenfeldt
影响因子：
2.9
作者：
W. Williams
通讯作者：
W. Williams
影响因子：
2.9
作者：
B. Daunter;E. Chantler;M. Elstein
通讯作者：
B. Daunter;E. Chantler;M. Elstein
影响因子：
5.8
作者：
Crowley, MM;Schroeder, B;McGinity, JW
通讯作者：
McGinity, JW