Past, present and future perspectives in nonalcoholic fatty liver disease
Past, present and future perspectives in nonalcoholic fatty liver disease
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DOI：
10.1038/s41575-019-0144-8
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发表时间：
2019-06-01
影响因子：
65.1
通讯作者：
Sanyal, Arun J.
中科院分区：
文献类型：
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作者：
Sanyal, Arun J.
非酒精性脂肪性肝病（NAFLD）在四十年前首次被描述为一种独特的临床实体。然而，由于其高患病率和对一般人群中终末期肝病负担的日益增长的贡献，该疾病已成为肝病学关注的中心。该观点概述了与NAFLD相关的知识发展，重点是影响当前范式的里程碑式发现以及需要填补以取得进展的关键知识差距。具体而言，提供了基本疾病机制（重点是人类数据）的科学发现的时间轴和关于疾病临床过程的知识的演变，并且与治疗和最终预防NAFLD的当前方法相关。
Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four decades ago. However, the condition has become the centre of attention within hepatology owing to its high prevalence and growing contribution to the burden of end-stage liver disease in the general population. This Perspective provides an overview on the development of knowledge related to NAFLD with a focus on landmark findings that have influenced current paradigms and key knowledge gaps that need to be filled to make progress. Specifically, a timeline of scientific discovery of both basic disease mechanisms (with a focus on human data) and the evolution of knowledge about the clinical course of the disease is provided and related to current approaches to treat and eventually prevent NAFLD.