Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials
Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials
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DOI：
10.1016/j.neulet.2004.04.029
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发表时间：
2004-06-17
影响因子：
2.5
通讯作者：
Cerbo, R
中科院分区：
文献类型：
--
作者：
de Tommaso, M;Libro, G;Cerbo, R
在偏头痛患者中，硝酸甘油(NTG)会导致严重的延迟性头痛，类似于自发性偏头痛发作。本研究的目的是评价NTG激光诱发电位(LEP)的特征、波幅和对激光刺激的痛觉。入选患者9例。通过口服0.6 mg NTG诱发头痛，通过放置在顶端的圆盘电极记录信号，并指向相连的耳垂。在类似自发性偏头痛的中、重度头痛发作后，以及头痛阶段结束后至少72h，对刺激双手背侧和左右眶上区传递的CO2-LEP进行评估。当刺激两个眶上区时，患者在头痛期间表现出明显的热痛阈值降低和LEPS幅度增加。基于神经元对整合-伤害性结构的影响，NTG似乎支持一种可靠的偏头痛实验模型。在NTG诱导的头痛过程中，LEPS的易化可能与伤害性皮质的过度活动以及痛觉抑制控制的失败有关。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
In migraineurs nitroglycerin (NTG) induces severe delayed headache, resembling spontaneous migraine attacks. The aim of the present study was to evaluate NTG laser evoked potentials (LEP) features amplitude and pain sensation to laser stimuli during NTG-induced headache. Nine patients were selected. Headache was induced by oral administration of 0.6 mg of NTG; signals were recorded through disk electrodes placed at the vertex and referred to linked earlobes. CO2-LEPs delivered by stimulation of the dorsum of both hands and the right and left supraorbital zones were evaluated after the onset of moderate or severe headache resembling spontaneous migraine and at least 72 h after the end of the headache phase. Patients exhibited a significant heat pain threshold reduction and an LEPs amplitude increment during headache when both the supraorbital zones were stimulated. NTG appeared to support a reliable experimental model of migraine, based on the neuronal effects on the integrative-nociceptive structures. The LEPs facilitation during NTG-induced headache may be subtended by a hyperactivity of nociceptive cortex as well as by a failure of pain-inhibitory control. (C) 2004 Elsevier Ireland Ltd. All rights reserved.