Compartmentalization of brain energy metabolism between glia and neurons: Insights from mathematical modeling
Compartmentalization of brain energy metabolism between glia and neurons: Insights from mathematical modeling
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DOI：
10.1002/glia.20360
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发表时间：
2007-09-01
期刊：
影响因子：
6.2
通讯作者：
Costalat, Robert
中科院分区：
文献类型：
--
作者：
Aubert, Agnes;Costalat, Robert
我们回顾了代谢途径的数学模型在研究神经元和胶质细胞之间的大脑能量代谢区划方面的贡献。我们特别关注乳酸在胶质细胞和神经元之间的关系中的作用，以及星形胶质细胞-神经元乳酸穿梭(ANLS)的可能存在。我们首先讨论与神经元-神经胶质细胞相互作用相关的葡萄糖、丙酮酸和乳酸动力学模型。然后，我们回顾了能量代谢分区模型，这些模型涉及“红色”和“白色”刺激的概念，以及ANLS假说。接下来，我们展示了一项模型稳健性研究对关于乳酸在胶质细胞和神经元之间的代谢相互作用中的潜在作用的辩论的贡献。最后，我们讨论了模型对进一步实验研究的可能意义。(C)2007年Wiley-Liss，Inc.
We review the contribution of mathematical modeling of metabolic pathways to the study of the compartmentalization of brain energy metabolism between neurons and glia. We especially focus on the role of lactate in the relationship between glia and neurons and the possible presence of an astrocyte-neuron lactate shuttle (ANLS). We first discuss models of glucose, pyruvate, and lactate kinetics, which are relevant to neuron-glia interactions. We then review models of compartmentalized energy metabolism, which deal with the concepts of 'red' and 'white' stimulations, and the ANLS hypothesis. We next show the contribution of a study of model robustness to the debate about the potential role of lactate in metabolic interactions between glia and neurons. Finally, we discuss the possible implications of modeling for further experimental studies. (C) 2007 Wiley-Liss, Inc.