The μ opiate receptor as a candidate gene for pain:: Polymorphisms, variations in expression, nociception, and opiate responses
The μ opiate receptor as a candidate gene for pain:: Polymorphisms, variations in expression, nociception, and opiate responses
复制标题
DOI：
10.1073/pnas.96.14.7752
复制
发表时间：
1999-07-06
影响因子：
11.1
通讯作者：
Wang, ZJ
中科院分区：
文献类型：
--
作者：
Uhl, GR;Sora, I;Wang, ZJ
人个体之间和小鼠品系之间在μ阿片受体（μ OR）表达水平、对疼痛刺激的反应和对阿片类药物的反应方面存在差异。造成这些差异的最佳候选者之一是mu OR基因位点的变异。支持这一想法的是对人类和小鼠μ OR基因的分析。对人类mu OR表达的个体差异的评估增加了进一步的支持。对小鼠的研究，包括敲除转基因、数量性状基因座和品系比较研究，也强烈支持μ OR基因等位基因可能是导致人类伤害感受和阿片类药物反应个体差异的强有力候选基因。本文综述了目前的分析，小鼠和人类的μ OR基因，其重要的变种，这些变种和阿片类药物对疼痛的影响之间的相关性。
There are differences between human individuals and between mouse strains in levels of mu opiate receptor (mu OR) expression, responses to painful stimuli, and responses to opiate drugs. One of the best candidates for contributing to these differences is variation at the mu OR gene locus. Support for this idea comes from analyses of the human and murine mu OR genes. Assessments of individual differences in human mu OR expression add further support. Studies with mice, including knockout-transgenic, quantitative trait locus, and, strain-comparison studies, also strongly support the possibility that mu OR gene alleles would be strong candidates for contributing to individual differences in human nociception and opiate drug responses. This paper reviews current analyses of the murine and human mu OR genes, their important variants, and correlations between these variants and opiate influences on pain.