A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals.
A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals.
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新型锌 62/铜 62 发生器作为 PET 放射性药物的铜 62 源。
DOI：
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发表时间：
1989
影响因子：
9.3
通讯作者：
A. Yokoyama
中科院分区：
文献类型：
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作者：
Y. Fujibayashi;K. Matsumoto;Y. Yonekura;J. Konishi;A. Yokoyama
根据Zn和Cu络合物形成的差异，设计了一种新型的62 Zn/62 Cu发生器系统，为正电子发射断层显像放射性药物提供了一种易得的62 Cu源。当甘氨酸溶液（200 mM）用作洗脱剂时，非载体添加的62 Cu作为甘氨酸络合物从62 Zn吸附的阳离子交换树脂（CG-120，Amberlite）选择性洗脱。62 Cu的洗脱效率和放射性核素纯度分别为70%和大于99.9%。甘氨酸溶液中的铜显示出与二缩氨基硫脲的快速络合物形成，二缩氨基硫脲是用于双功能螯合放射性药物的确定的铜结合剂之一。
A new 62Zn/62Cu generator system was designed to provide a readily available 62Cu source for positron emission tomographic radiopharmaceuticals, based on the differences of complex formation between Zn and Cu. Noncarrier added 62Cu was selectively eluted as a glycine complex from 62Zn-adsorbed cation-exchange resin (CG-120, Amberlite), when a glycine solution (200 mM) was used as the eluant. The elution efficiency and radionuclidic purity of 62Cu were 70% and greater than 99.9%, respectively. Copper in glycine solution showed rapid complex formation with dithiosemicarbazone, which is one of the established Cu-binding agents for bifunctional chelating radiopharmaceutical.