Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
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DOI：
10.1161/01.cir.0000055188.83694.b3
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发表时间：
2003-02-11
期刊：
影响因子：
37.8
通讯作者：
Matsuzawa, Y
中科院分区：
文献类型：
--
作者：
Ouchi, N;Kihara, S;Matsuzawa, Y
高敏C反应蛋白（hs-CRP）是众所周知的冠状动脉疾病（CAD）的危险因素。近年来，我们发现脂联素是一种由脂肪细胞特异性分泌的抗动脉粥样硬化的血浆蛋白。本研究探讨了脂联素和CRP在血流和脂肪tissue.Methods和结果之间的关联，我们研究了共101例男性患者，其中71例有血管造影记录的冠状动脉粥样硬化。对照组30例，冠状动脉造影正常。血浆hs-CRP水平与血浆脂联素水平呈负相关（r=-0.29，P
Background-High-sensitive C-reactive protein (hs-CRP) is a well-known risk factor for coronary artery disease (CAD). Recently, we have demonstrated that adiponectin served as an antiatherogenic plasma protein which was secreted specifically from adipocytes. The present study investigated the association between adiponectin and CRP in the blood stream and adipose tissue.Methods and Results-We studied a total of 101 male patients, 71 of whom had angiographically documented coronary atherosclerosis. As a control group, 30 patients with normal coronary angiogram were included. The plasma hs-CRP levels were negatively correlated with the plasma adiponectin levels (r= -0.29, P