Persistence of antibody and response to booster dose of Haemophilus influenzae type b polysaccharide diphtheria toxoid conjugate vaccine in infants immunized at 9 to 15 months of age.
Persistence of antibody and response to booster dose of Haemophilus influenzae type b polysaccharide diphtheria toxoid conjugate vaccine in infants immunized at 9 to 15 months of age.
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在 9 至 15 个月大的婴儿中，抗体的持久性和对 B 型流感嗜血杆菌多糖白喉类毒素结合疫苗加强剂量的反应。
DOI：
10.1016/s0022-3476(86)80921-0
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Gordon,L
中科院分区：
文献类型：
--
作者：
Lepow,M;Randolph,M;Cimma,R;Larsen,D;Rogan,M;Schumacher,J;Lent,B;Gaintner,S;Samuelson,J;Gordon,L
在大约2岁时，27名在9~15个月龄时预先接种了两剂聚核糖基磷酸核糖醇-白喉类毒素结合疫苗(PRP-D)的婴儿和23名接种了PRP-D疫苗的婴儿单次注射PRP-D。取免疫前和免疫后血清。未观察到严重的局部或全身反应。二次免疫后1个月几何平均抗体水平为4.8μg/ml，1年后仍为1.2μg/ml，加强免疫后抗体水平为71μg/ml。相比之下，在第二次初次接种后1个月，PRP接受者的几何平均水平为0.083μg/ml，1年后保持在0.042μg/ml，在大约2岁时单次注射PRP-D后，几何平均水平为8.6μg/ml。
At approximately 2 years of age, 27 infants prevlously immunized at 9 to 15 months of age with two doses of polyribosylribifol phosphate-diphtheria toxoid conjugate vaccine (PRP-D) and 23 infants immunized with polyribosyiribitol phosphate (PRP) vaccine were given a single injection of PRP-D. Pre- and post-immunization sera were obtained. No serious local or systemic reactions were observed. The PRP-D reciplents had a geometric mean anti-PRP antibody level of 4.8 μg/ml 1 month after the second primary injection, retained 1.2 μg/ml 1 year later, and had a level of 71 μg/ml after the booster immunization. In contrast, PRP recipients had a geometric mean level of 0.083 μg/ml 1 month after the second primary injection, retained 0.042 μg/ml 1 year later, and after a single dose of PRP-D at approximately 2 years of age had a geometric mean level of 8.6 μg/ml. The significantly higher antibody response in the prior PRP-D recipients suggests the recall of immunologic memory induced by the PRP-D vaccine.