In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity
In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity
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新型碳青霉烯类抗生素 BO-2727 的体外活性，具有有效的抗假单胞菌活性
DOI：
10.1128/aac.37.12.2756
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发表时间：
1993
影响因子：
4.9
通讯作者：
Nobuo Tanaka
中科院分区：
文献类型：
--
作者：
Susumu Nakagawa;Terutaka Hashizume;K. Matsuda;M. Sanada;Osamu Okamoto;H. Fukatsu;Nobuo Tanaka
BO-2727是一种新的1- β -甲基-碳青霉烯烯类化合物，在6.25微克/毫升或更低浓度下对革兰氏阳性和革兰氏阴性细菌，包括对亚胺培南和/或美罗培南耐药（mic, >或= 12.5微克/毫升）的铜绿假单胞菌具有活性，其活性一般比亚胺培南和美罗培南高4倍。BO-2727在肾脱氢肽酶I存在下是稳定的，其抗假单胞菌活性和广谱谱值得进一步研究用于临床应用。
BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more active than imipenem and meropenem. BO-2727's antipseudomonal activity and its broad spectrum merit further investigation for clinical use by itself, since it was stable in the presence of renal dehydropeptidase I.