Measurement of blood perfusion using the temperature response to constant surface flux heating
Measurement of blood perfusion using the temperature response to constant surface flux heating
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DOI：
10.1023/a:1020798119128
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发表时间：
2002-11-01
影响因子：
2.2
通讯作者：
Yi, YF
中科院分区：
文献类型：
--
作者：
Li, HJ;Zhang, XX;Yi, YF
针对皮肤组织在恒定表面热流作用下的温度分布，建立了Pennes生物热方程的封闭解析解。在表面温度的升高被发现是相关的血液灌注率和热通量的基础上，一个新的非侵入性的方法已经开发出来，以确定血液灌注率。温度升高对血液灌注和热通量的敏感性进行了研究，热接触电阻对灌注估计的影响也是如此。已经证明，这种影响相对较小，并且可以通过应用高导电性润滑脂来有效地消除。开发了用于该方法的实验系统，并使用该系统测量了包括前臂、大腿和小腿在内的各种人体部位的血液灌注率。皮肤组织的血液灌注率在4 ~ 6 kg·s（-1）·m（-3）范围内，与文献报道的结果一致。
A closed-form analytical solution of the Pennes bio-heat equation was developed for the temperature distribution in skin tissue subjected to a constant surface heat flux. Elevations in the surface temperature were revealed to be related to blood perfusion rates and heating fluxes based on which a new noninvasive approach has been developed to determine the blood perfusion rates. Sensitivities of the temperature elevation to blood perfusion and heating flux were investigated, as was the influence of thermal contact resistance on the perfusion estimate. It has been demonstrated that this influence is relatively small and can be effectively eliminated by application of highly conductive grease. An experimental system for this method was developed, and the blood perfusion rates in various human locations, including forearm, thigh, and calf, were measured using the system. The blood perfusion rate of skin tissue is in the range of 4 to 6 kg.s(-1).m(-3), which is in good agreement with those reported in the literature.