Organometallic-Constructed Tip-Based Dual Chemical Sensing by Tip-Enhanced Raman Spectroscopy for Diabetes Detection.
Organometallic-Constructed Tip-Based Dual Chemical Sensing by Tip-Enhanced Raman Spectroscopy for Diabetes Detection.
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DOI：
10.1021/acsami.8b11950
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发表时间：
2018-11
影响因子：
9.5
通讯作者：
Duo Lin;Yi-Cheng Lin;Shang-wei Yang;Lan Zhou;W. Leong;Shangyuan Feng;K. Kong
中科院分区：
文献类型：
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作者：
Duo Lin;Yi-Cheng Lin;Shang-wei Yang;Lan Zhou;W. Leong;Shangyuan Feng;K. Kong
尖端增强拉曼光谱（TERS）能够以高灵敏度探测特定的分子信息，但双重化学传感仍然是一个挑战。在生物样品如血液中进行TERS化学检测的另一个主要障碍是来自生物分子的强吸收的干扰。在这里，我们报告的有机金属共轭TERS尖端的制备。我们证明，有机金属化学可以完美地耦合TERS的双分子传感。有机金属化合物产生的独特拉曼信号避免了血液中生物分子的信号干扰，从而可以快速分析超低体积（50 nL）样品中的两种重要分子（葡萄糖和硫醇）。这使得非糖尿病患者和糖尿病患者血液中巯基和葡萄糖水平之间的相关性得以绘制。
Tip-enhanced Raman spectroscopy (TERS) is capable of probing specific molecular information with high sensitivity, but dual chemical sensing remains a challenge. Another major hindrance to TERS chemical detection in biosamples such as blood is the interference from the strong absorptions of biomolecules. Herein, we report the preparation of an organometallic-conjugated TERS tip. We demonstrate that organometallic chemistry can be perfectly coupled with TERS for dual-molecule sensing. The unique Raman signals generated by the organometallic compound circumvent signal interference from the biomolecules in blood, allowing the rapid analysis of two important molecules (glucose and thiol) in ultralow volume (50 nL) samples. This enabled a correlation between the thiol and glucose levels in the blood of nondiabetic and diabetic patients to be drawn.