Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses
Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses
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DOI：
10.1016/j.virol.2008.01.029
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发表时间：
2008-05-10
期刊：
影响因子：
3.7
通讯作者：
Mullins, James I.
中科院分区：
文献类型：
--
作者：
Liu, Yi;Curlin, Marcel E.;Mullins, James I.
Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites. (c) 2008 Elsevier Inc. All rights reserved.
