Alternative thermodiffusion interface for simultaneous speciation of m organic and inorganic lead and mercury species by capillary GC-ICPMS using tri-n-propyl-lead chloride as an internal standard
Alternative thermodiffusion interface for simultaneous speciation of m organic and inorganic lead and mercury species by capillary GC-ICPMS using tri-n-propyl-lead chloride as an internal standard
复制标题
使用三正丙基氯化铅作为内标，通过毛细管 GC-ICPMS 同时形成多种有机和无机铅和汞形态的替代热扩散接口
DOI：
10.1021/ac800347j
复制
发表时间：
2008-08-01
影响因子：
7.4
通讯作者：
Wang, Qiuquan
中科院分区：
文献类型：
--
作者：
Yan, Dong;Yang, Limin;Wang, Qiuquan
An alternative thermodiffusion interface (TDI) was designed and constructed for the effective online coupling of capillary gas chromatography (cGC) and inductively coupled plasma mass spectrometry (ICPMS). Pb2+, (CH3)(3)Pb+, (C2H5)(3)Pb+, Hg2+, CH3Hg+ and C2H5Hg+ were derived as Pb(C4H9)(4), (CH3)(3)PbC4H9, (C2H5)(3)PbC4H9, (C4H9)(2)Hg, CH3HgC4H9, and C2H5HgC4H9 when butyl magnesium bromide was employed as a derivatization reagent for a proof-of-concept study, avoiding the loss of their species specific information. All these derivatives together with the neutral fully saturated (CH3)(4)Pb and (C2H5)(4)Pb could be quantitatively separated within 7 min using a 15 m long capillary column, allowing the determination and speciation of organic and inorganic Pb and Hg species in a single run. The method detection limits (3 sigma) for Me4Pb, Et4Pb, Me3Pb3+, Pb2+, MeHg+, EtHg+, and Hg2+ are 0.07, 0.06, 0.04, 7.0, 0.09, 0.1, and 0.2 pg g(-1), respectively. Moreover, tri-n-propyl-lead chloride was synthesized and used as an alternative internal standard for the accurate and simultaneous speciation analysis of Pb and Hg in complicated environmental and biological samples for the first time. This cGC-TDI-ICPMS method was validated by analyzing Pb and Hg species in certified reference materials and then was applied to simultaneous speciation analysis of Pb and Hg in real-life samples. It is expected that these approaches can be extended to the speciation of other organometallic compounds after suitable modifications and so will aid in monitoring the occurrence, pathways, toxicity, and/or biological effects of these compounds in the environment and in organisms.
