Stressful life events, genetic liability, and onset of an episode of major depression in women.
Stressful life events, genetic liability, and onset of an episode of major depression in women.
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女性的压力生活事件、遗传倾向和重度抑郁症的发作。
DOI：
10.1176/ajp.152.6.833
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Eaves,LJ
中科院分区：
文献类型：
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作者：
Kendler,KS;Kessler,RC;Walters,EE;MacLean,C;Neale,MC;Heath,AC;Eaves,LJ
本研究旨在阐明遗传易感性和应激性生活事件在重性抑郁症病因学中的相互作用。方法收集了2,164例女性双胞胎样本中有关应激性生活事件和过去一年中重性抑郁发作的信息，观察53,215人月，结果9个“个人”和3个聚集的“网络”压力事件显著预测了发生月的抑郁症发作，其中4个事件预测的发病优势比>10，被称为“严重”：近亲死亡、殴打、严重的婚姻问题和离婚/分手。遗传易感性对抑郁症的发病风险也有显著影响。四个严重的压力事件，以及10的12个人的压力事件，最适合的模型的压力事件和遗传易感性的联合作用，对抑郁症的发病建议遗传控制的敏感性，抑郁症的诱导影响的压力生活事件。在遗传风险最低的个体（同卵双胞胎，双胞胎未受影响）中，对于未暴露和暴露于严重事件的个体，每月发生重度抑郁症的概率分别为0.5%和6.2%。在那些遗传风险最高的人（同卵双胞胎，双胞胎）中，这些概率分别为1.1%和14.6%。线性回归分析表明显着的基因型环境相互作用的预测发病的抑郁症。ConclusionsGenetic factors affect the risk of onset of major depression in part by changing the sensitivity of independence of depression-inducing effect of stressed life events.（经美国精神病学杂志许可转载，1995年; 152：833-842）
ObjectiveThis study was undertaken to clarify how genetic liability and stressful life events interact in the etiology of major depression.MethodInformation about stressful life events and onset of major depressive episodes in the past year was collected in a population-based sample of female-female twin pairs including 2,164 individuals, 53,215 person-months of observation, and 492 onsets of depression.ResultsNine “personal” and three aggregate “network” stressful events significantly predicted onset of major depression in the month of occurrence, four of which predicted onset with an odds ratio of >10 and were termed “severe”: death of a close relative, assault, serious marital problems, and divorce/breakup. Genetic liability also had a significant impact on risk of onset of depression. Four severe stressful events, as well as for 10 of the 12 individuals stressful events, the best-fitting model for the joint effect of stressful events and genetic liability on onset of major depression suggested genetic control of sensitivity to the depression-inducing effects of stressful life events. In individuals at lowest genetic risk (monozygotic twin, co-twin unaffected), the probability of onset of major depression per month was predicted to be 0.5% and 6.2%, respectively, for those unexposed and exposed to a severe event. In those at highest genetic risk (monozygotic twin, co-twin affected), these probabilities were 1.1% and 14.6%, respectively. Linear regression analysis indicated significant Genotype by Environment interaction in the prediction of onset of major depression.ConclusionsGenetic factors influence the risk of onset of major depression in part by altering the sensitivity of individuals to the depression-inducing effect of stressful life events.(Reprinted with permission from The American Journal of Psychiatry 1995; 152:833–842)