Photopheresis: present and future aspects.
Photopheresis: present and future aspects.
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光采：现在和未来的方面。
DOI：
10.1016/1011-1344(91)80221-3
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Edelson,RL
中科院分区：
文献类型：
--
作者：
Edelson,RL
在1990年10月纽约科学院关于“抗原和克隆特异性免疫调节”的会议上，介绍了与光分离直接相关的许多基础和临床研究。该次会议的会议记录将于1991年7月出版，提供对这一问题的最新和最详细的审查。这篇综述将突出那里报道的最突出的观察结果。光分离是一种似乎对某些循环T细胞障碍患者有效的治疗方法。关于它的作用模式，为什么一些患者反应良好而另一些患者反应不佳，以及管理它的最佳方式，仍有许多需要了解。然而，自从最初偶然发现光分离术在前五名红皮病型皮肤T细胞淋巴瘤患者中的两名患者中产生了令人惊讶的深刻反应以来，在过去8年中，在临床和科学方面都取得了重大进展。目前，该手术已在美国50多家医疗中心以及欧洲、日本和澳大利亚的几家医院实施。
At a New York Academy of Sciences meeting in October 1990 on “Antigen and Clone Specific Immunoregulation”, much of the basic and clinical research relating directly to photopheresis was presented. The proceedings of that meeting will be published in July of 1991, providing the most updated and detailed review of the subject. This overview will highlight the most salient observations reported there.Photopheresis is a treatment that appears to be efficacious in the management of certain patients with disorders of circulating T cells. Much remains to be learned about its mode of action, about why some patients respond well and others do not and about the best way to administer it. Yet, major progress has been made over the past 8 years on both the clinical and scientific fronts, since the initial chance discovery that photopheresis produced a surprisingly profound response in two of the first five patients with erythrodermic cutaneous T cell lymphoma. The procedure is now operative in more than 50 medical centers in the US and in several hospitals in Europe, Japan and Australia.