Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives.
Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives.
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DOI：
10.1016/j.tips.2021.07.002
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发表时间：
2021-10
影响因子：
13.8
通讯作者：
Mochly-Rosen D
中科院分区：
文献类型：
--
作者：
Garcia AA;Koperniku A;Ferreira JCB;Mochly-Rosen D
Glucose-6-phosphate dehydrogenase (G6PD) maintains redox balance in a variety of cell types and is essential for erythrocyte resistance to oxidative stress. G6PD deficiency, caused by mutations in the G6PD gene, is present in ~400 million people worldwide, and can cause acute hemolytic anemia. Currently, there are no treatments for G6PD deficiency. We discuss the role of G6PD in hemolytic and non-hemolytic disorders, treatment strategies attempted over the years, and potential reasons for their failure. We also discuss potential pharmacological pathways, including glutathione metabolism, compensatory NADPH production routes, transcriptional upregulation of the G6PD gene, highlighting potential drug targets. The needs and opportunities described here may motivate the development of a therapeutic for hematological and other chronic diseases associated with G6PD deficiency.
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DOI：
10.1016/j.ijbiomac.2017.06.002
发表时间：
2017-11
影响因子：
8.2
作者：
Boonyuen U;Chamchoy K;Swangsri T;Junkree T;Day NPJ;White NJ;Imwong M
通讯作者：
Imwong M
影响因子：
20.8
作者：
Chen, Li;Zhang, Zhaoyue;Rabinowitz, Joshua D.
通讯作者：
Rabinowitz, Joshua D.
DOI：
10.1016/j.vascn.2016.10.002
发表时间：
2017-03-01
影响因子：
1.9
作者：
Amini, Naser;Vousooghi, Nasim;Joghataei, Mohammad Taghi
通讯作者：
Joghataei, Mohammad Taghi
G6PD过表达可保护氧化应激和与年龄相关的听力损失。
影响因子：
7.8
作者：
Bermúdez-Muñoz JM;Celaya AM;Hijazo-Pechero S;Wang J;Serrano M;Varela-Nieto I
通讯作者：
Varela-Nieto I
影响因子：
2.1
作者：
Cunningham AD;Hwang S;Mochly-Rosen D
通讯作者：
Mochly-Rosen D