Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: A meta-analytic comparison of randomized controlled trials
Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: A meta-analytic comparison of randomized controlled trials
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DOI：
10.1016/j.schres.2012.03.017
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发表时间：
2012-09-01
影响因子：
4.5
通讯作者：
Maayan, Lawrence
中科院分区：
文献类型：
--
作者：
Caemmerer, Jacqueline;Correll, Christoph U.;Maayan, Lawrence
目的：评价非药物干预对抗精神病药物相关性体重增加的疗效。方法：系统性文献检索和随机对照试验的荟萃分析，比较行为干预与对照组改善抗精神病药物相关性体重增加。结果：在17项研究中（n=810，平均年龄：38.8岁，52.7%男性，40.8%白色，85.6%精神分裂症谱系障碍），非药物干预导致体重显著降低（-3.12 kg; CI：-4.03，-2.21，p= 7%（29.7% vs. 61.3%; RR=-0.52，CI：-0.35，-0.78，p=0.002;需要治疗的数量=4）。干预结束后12个月（平均=3.6个月），体重（WMD=-3.48 kg，CI：-6.37，-0.58，p=0.02）而非BMI（p=0.40）方面的获益持续存在。亚组分析显示，无论治疗持续时间、个体或群体、认知行为或营养干预，或预防与干预试验如何，非药物干预均具有优效性。然而，体重和BMI仅在门诊试验中有显著改善（p
Objective: To evaluate the efficacy of non-pharmacological interventions for antipsychotic-associated weight gain.Methods: Systematic literature search and meta-analysis of randomized controlled trials comparing behavioral interventions with control groups to ameliorate antipsychotic-associated weight gain.Results: Across 17 studies (n=810, mean age: 38.8 years, 52.7% male, 40.8% White, 85.6% with schizophrenia-spectrum disorders), non-pharmacological interventions led to a significant reduction in weight (-3.12 kg; CI: -4.03, -2.21, p= 7% (29.7% vs. 61.3%; RR=-0.52, CI:-0.35,-0.78, p=0.002; number-needed-to-treat=4). Up to 12 months after the intervention ended (mean=3.6 months), benefits endured regarding weight (WMD=-3.48 kg, CI: -6.37, -0.58, p=0.02), but not BMI (p=0.40). Subgroup analyses showed superiority of non-pharmacological interventions irrespective of treatment duration, individual or group, cognitive behavioral or nutritional interventions, or prevention versus intervention trials. However, weight and BMI were significantly improved only in outpatient trials (p