Perinatal inflammation and childhood adiposity - a gender effect?
Perinatal inflammation and childhood adiposity - a gender effect?
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DOI：
10.1080/14767058.2018.1517315
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发表时间：
2020-04-02
影响因子：
1.8
通讯作者：
McAuliffe, Fionnuala M.
中科院分区：
文献类型：
--
作者：
Donnelly, Jean M.;Lindsay, Karen;McAuliffe, Fionnuala M.
背景：独立于瘦素，确定母体和胎儿炎症因子与特定性别的婴儿肥胖的相关性。方法：对265对孕期低血糖指数饮食的随机对照试验(ROLO)研究(低血糖指数饮食的随机对照试验)的265对母婴和280对6个月时的母婴进行人体测量学分析，并测定其与妊娠早期和晚期母体肿瘤坏死因子-α、白介素6和瘦素的关系以及脐血中胎儿的水平。结果：在男性队列中没有发现关联。在女性新生儿队列中，晚孕IL-6与皮褶总数呈负相关(P
Background: To determine the association of maternal and fetal inflammatory factors with gender-specific infant adiposity, independent of leptin. Methods: Analysis of anthropometry from 265 mother-infant pairs at birth and 280 pairs at 6 months from the randomised control trial of low glycaemic index diet in pregnancy (ROLO) study (Randomised control trial of low glycaemic index diet) and their association with Maternal TNF-alpha, interleukin 6 and leptin as measured in early and late pregnancy and fetal levels in cord blood. Results: No associations were noted in the male cohort. On multiple regression amongst the female neonatal cohort late pregnancy IL-6 was inversely associated with sum of skinfolds (p