In vitro survey of triazole cross-resistance among more than 700 clinical isolates of Aspergillus species
In vitro survey of triazole cross-resistance among more than 700 clinical isolates of Aspergillus species
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DOI：
10.1128/jcm.00535-08
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发表时间：
2008-08-01
影响因子：
9.4
通讯作者：
Diekema, D. J.
中科院分区：
文献类型：
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作者：
Pfaller, M. A.;Messer, S. A.;Diekema, D. J.
很少有数据描述大量临床曲霉分离株（包括烟曲霉以外的菌种）之间的体外交叉耐药模式。我们检测了771个曲霉属。作为全球抗真菌监测项目的一部分，从2000年到2006年收集的临床分离株（553 A. fumigatus，76 A. flavus，59 A.尼日尔，35 A. terreus和24 A.杂色曲霉菌株和24个其它曲霉属物种的菌株）。通过临床和实验室标准化研究所（CLSI）M38-A肉汤稀释法使用伊曲康唑（ITR）、泊沙康唑（POS）、雷康唑（RAV）和伏立康唑（VOR）进行抗真菌药敏试验。我们研究了潜在的交叉耐药性，通过使用相关性的措施，整体和物种。对于大多数曲霉属分离株（从ITR的88%分离株到VOR和POS的98%分离株），每种三唑的MIC为2 μ g/ml仍然是极其罕见的（< 1%的分离株）。
Few data exist to describe in vitro patterns of cross-resistance among large collections of clinical Aspergillus isolates, including those of species other than Aspergillus fumigatus. We examined 771 Aspergillus spp. clinical isolates collected from 2000 to 2006 as part of a global antifungal surveillance program ( 553 A. fumigatus, 76 A. flavus, 59 A. niger, 35 A. terreus, and 24 A. versicolor isolates and 24 isolates of other Aspergillus species). Antifungal susceptibility testing was performed by the Clinical and Laboratory Standards Institute ( CLSI) M38-A broth dilution method with itraconazole ( ITR), posaconazole ( POS), ravuconazole ( RAV), and voriconazole ( VOR). We examined the potential for cross-resistance by using measures of correlation overall and by species. For most Aspergillus isolates ( from 88% of isolates for ITR to 98% of isolates for VOR and POS), MICs of each triazole were 2 mu g/ml remain extremely rare (< 1% of isolates).